Chromatin loops and domains are major organizational hallmarks of chromosomes. New work suggests, however, that these topological features of the genome are poor global predictors of gene activity, raising questions about their function.
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Finn, E.H., Misteli, T. A genome disconnect. Nat Genet 51, 1205–1206 (2019). https://doi.org/10.1038/s41588-019-0476-x
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