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3D GENOMICS

A genome disconnect

Chromatin loops and domains are major organizational hallmarks of chromosomes. New work suggests, however, that these topological features of the genome are poor global predictors of gene activity, raising questions about their function.

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Fig. 1: Using balancer chromosomes to probe the relationship between genome architecture and function.

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Correspondence to Tom Misteli.

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Finn, E.H., Misteli, T. A genome disconnect. Nat Genet 51, 1205–1206 (2019). https://doi.org/10.1038/s41588-019-0476-x

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