Epigenetic heterogeneity underlies the diversity of cell states found in health and disease. A new study presents a method for profiling of histone modifications in single cells and applies it to identify rare chromatin states, possibly predisposed to drug resistance, within patient-derived tumor xenografts.
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The authors declare no competing interests.
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Minkina, A., Shendure, J. Expanding the single-cell genomics toolkit. Nat Genet 51, 931–932 (2019). https://doi.org/10.1038/s41588-019-0429-4