Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

SINGLE-CELL TECHNOLOGY

Expanding the single-cell genomics toolkit

Nature Genetics volume 51, pages 931–932 (2019)Cite this article

Subjects

Epigenetic heterogeneity underlies the diversity of cell states found in health and disease. A new study presents a method for profiling of histone modifications in single cells and applies it to identify rare chromatin states, possibly predisposed to drug resistance, within patient-derived tumor xenografts.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: scChIP–seq for single-cell histone-modification profiling.

References

  1. Rathert, P. et al. Nature 525, 543–547 (2015).

    Article  CAS  Google Scholar 

  2. Kim, C. et al. Cell 173, 879–893.e13 (2018).

    Article  CAS  Google Scholar 

  3. Hwang, B., Lee, J. H. & Bang, D. Exp. Mol. Med. 50, 96 (2018).

    Article  Google Scholar 

  4. Cusanovich, D. A. et al. Science 348, 910–914 (2015).

    Article  CAS  Google Scholar 

  5. Buenrostro, J. D. et al. Nature 523, 486–490 (2015).

    Article  CAS  Google Scholar 

  6. Cusanovich, D. A. et al. Cell 174, 1309–1324.e18 (2018).

    Article  CAS  Google Scholar 

  7. Grosselin, K. et al. Nat. Genet. https://doi.org/10.1038/s41588-019-0424-9 (2019).

    Article  PubMed  Google Scholar 

  8. Rotem, A. et al. Nat. Biotechnol. 33, 1165–1172 (2015).

    Article  CAS  Google Scholar 

  9. Zhang, X. et al. Mol. Cell 73, 130–142.e5 (2019).

    Article  CAS  Google Scholar 

  10. Cao, J. et al. Nature 566, 496–502 (2019).

    Article  CAS  Google Scholar 

  11. Clark, S. J. et al. Nat. Commun. 9, 781 (2018).

    Article  Google Scholar 

  12. Cao, J. et al. Science 361, 1380–1385 (2018).

    Article  CAS  Google Scholar 

  13. Hainer, S. J., Bošković, A., McCannell, K. N., Rando, O. J. & Fazzio, T. G. Cell https://doi.org/10.1016/j.cell.2019.03.014 (2019).

    Article  Google Scholar 

  14. Merino, D. et al. Nat. Commun. 10, 766 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genome Sciences, University of Washington, Seattle, WA, USA

    Anna Minkina & Jay Shendure

  2. Brotman Baty Institute for Precision Medicine, Seattle, WA, USA

    Jay Shendure

  3. Allen Discovery Center for Cell Lineage Tracing, Seattle, WA, USA

    Jay Shendure

  4. Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA

    Jay Shendure

Authors
  1. Anna Minkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jay Shendure
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jay Shendure.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Minkina, A., Shendure, J. Expanding the single-cell genomics toolkit. Nat Genet 51, 931–932 (2019). https://doi.org/10.1038/s41588-019-0429-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-019-0429-4

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer