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Expanding the single-cell genomics toolkit

Epigenetic heterogeneity underlies the diversity of cell states found in health and disease. A new study presents a method for profiling of histone modifications in single cells and applies it to identify rare chromatin states, possibly predisposed to drug resistance, within patient-derived tumor xenografts.

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Fig. 1: scChIP–seq for single-cell histone-modification profiling.


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Correspondence to Jay Shendure.

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Minkina, A., Shendure, J. Expanding the single-cell genomics toolkit. Nat Genet 51, 931–932 (2019).

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