a, Scatter plots showing whole genome H3K36me3 enrichment (10kb window) between 500 cells (n = 1), 10k cells (n = 1) and ENCODE dataset in mESCs. Pearson correlation is also shown. b, Pearson correlations are shown for pairwise comparisons of H3K36me3 enrichment between individual sample. Analyses were done using two replicates for GO-P7, GO-P10, GO-P14, FGO, and MII oocytes, and one replicate for 500 and 10k mESCs. ENCODE H3K36me3 data of mESCs is used for comparison. c, Hierarchical clustering analysis of H3K36me3 in individual replicates of mouse early embryos at various stages or mESCs with various cell numbers. d, The dynamics of gene expression and histone modifications for genes activated between GO-P7 to GO-P14.