Supplementary Fig. 11: Aberrant epigenome in Setd2mNull 1-cell embryos. | Nature Genetics

Supplementary Fig. 11: Aberrant epigenome in Setd2mNull 1-cell embryos.

From: SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

Supplementary Fig. 11

a, Gene ontology of up- or down-regulated genes between Setd2mNull (n = 2) and control 1C (n = 2). P-values (t-test, two sided, not adjusted by multiple comparisons) are transformed by log10. b, Gene ontology of genes that are both up- or down-regulated between Setd2mNull and control in FGO (n = 2) and 1C embryos (n = 2). P-values (t-test, two sided, not adjusted by multiple comparisons) are transformed by log10. c, Heat map showing expression and H3K27me3 levels for genes that are both downregulated in Setd2mNull FGO and 1C embryos, and acquire ectopic H3K27me3 in Setd2mNull FGO or 1C embryos. Example genes are also shown. d, A heat map showing H3K4me3 enrichment in FGO and 1C for ‘H3K4me3-gain domains’ or ‘H3K4me3-loss domains’ defined in FGO (left). A similar analysis result was shown for H3K27me3 (right). e, Snapshots from UCSC genome browser showing allelic H3K4me3 (top) or H3K27me3 (bottom) enrichment in control and Setd2mNull zygotes. H3K4me3 and H3K27me3 in 1C embryos from a previous study are also shown as control. f, A bar chart showing the percentages of H3K4me3 or H3K27me3 reads assigned to the maternal (129 or C57BL/6) or paternal (PWK) allele in control and Setd2mNull 1C embryos.

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