Supplementary Fig. 6: Ectopic H3K27me3 correlates with the downregulation of gene expression in Setd2mNull FGOs. | Nature Genetics

Supplementary Fig. 6: Ectopic H3K27me3 correlates with the downregulation of gene expression in Setd2mNull FGOs.

From: SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

Supplementary Fig. 6

a, Heat maps showing differentially expressed genes (2-fold change) that also show altered H3K4me3 in gene bodies in Setd2mNull FGO. Promoter H3K4me3 levels are also mapped and shown. Genes showing changes in both gene expression and H3K4me3 were selected for this analysis. b, Heat maps showing differentially expressed genes (2-fold change) that also show alteration of H3K27me3 enrichment at gene bodies in Setd2mNull FGO. Promoter H3K27me3 levels are also mapped and shown. Genes showing changes in both gene expression and H3K27me3 were selected for this analysis. Gene ontology analysis and example genes are also shown on the right side. c, Scatter plot showing changes of gene expression and changes of H3K4me3 (n = 3) or H3K27me3 (n = 2) at promoters in Setd2mNull FGO, compared to control FGO (n = 2 for both H3K4me3 and H3K27me3). Pearson correlation coefficient is shown. d, A snapshot from UCSC browser showing H3K4me3, H3K27me3 and H3K36me3 enrichment in control and Setd2mNull FGO. Gene expression is also shown.

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