Supplementary Fig. 5: Setd2mNull GO-P7 oocytes share a similar epigenome with Setd2mNull FGOs. | Nature Genetics

Supplementary Fig. 5: Setd2mNull GO-P7 oocytes share a similar epigenome with Setd2mNull FGOs.

From: SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development

Supplementary Fig. 5

a, Snapshots from UCSC genome browser showing H3K4me3 and H3K27me3 enrichment in control and Setd2mNull GO-P7 and FGO oocytes. b, Box plots showing enrichment of H3K4me3 and H3K27me3 in control (Zhang et al., 2016) and Setd2mNull P7 oocytes (H3K4me3, n = 1; H3K27me3, n = 1) for regions defined as ‘K4me3-gain domains’, ‘K4me3-loss domains’, ‘K27me3-gain domains’, and ‘K27me3-loss domains’ in control and Setd2mNull FGO. Similar analysis was performed for transcription levels in control (n = 2) and Setd2mNull P7 oocytes (n = 2) for misregulated (up, upregulated; down, downregulated) genes in Setd2mNull FGO. The median of each dataset is shown by center line. The bottom, the top edges and whiskers represent the 25th, 75th percentiles and 1.5 times the interquartile range, respectively. P-values (t-test, two sided) are also shown. c, Hierarchical clustering analysis of global H3K4me3 and H3K27me3 distribution in control (Zhang et al., 2016) and Setd2mNull GO-P7 and FGO. d, Violin plot showing the levels of DNA methylation in control (GO-P7, n = 1; FGO, n = 2) and Setd2mNull oocytes (GO-P7, n = 1; FGO, n = 2) in GO-P7 and FGO. The outer shape indicates all results. The center dot indicates the median average value, and the thick and thin line represent the 50% and 95% value ranges, respectively.

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