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HUMAN GENETICS

Resolving variant-to-function relationships in hematopoiesis

Resolving variant-to-function relationships is a key challenge faced by human geneticists. A new study combining statistical fine-mapping with cell-type-specific functional annotations advances the understanding of the regulatory consequences of genetic variants associated with variations in blood-cell traits.

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Fig. 1: Switch versus tune mechanism for genetic variants.

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Correspondence to Nicole Soranzo.

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Tardaguila, M., Soranzo, N. Resolving variant-to-function relationships in hematopoiesis. Nat Genet 51, 581–583 (2019). https://doi.org/10.1038/s41588-019-0386-y

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