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HUMAN GENETICS

Resolving variant-to-function relationships in hematopoiesis

Nature Genetics volume 51, pages 581–583 (2019)Cite this article

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Resolving variant-to-function relationships is a key challenge faced by human geneticists. A new study combining statistical fine-mapping with cell-type-specific functional annotations advances the understanding of the regulatory consequences of genetic variants associated with variations in blood-cell traits.

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Fig. 1: Switch versus tune mechanism for genetic variants.

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Authors and Affiliations

  1. Human Genetics, Wellcome Sanger Institute, Hinxton, UK

    Manuel Tardaguila & Nicole Soranzo

  2. Department of Haematology, University of Cambridge, Cambridge, UK

    Nicole Soranzo

Authors
  1. Manuel Tardaguila
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  2. Nicole Soranzo
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Correspondence to Nicole Soranzo.

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The authors declare no competing interests.

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Tardaguila, M., Soranzo, N. Resolving variant-to-function relationships in hematopoiesis. Nat Genet 51, 581–583 (2019). https://doi.org/10.1038/s41588-019-0386-y

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