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Author Correction: Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes

The Original Article was published on 14 January 2019

Correction to: Nature Genetics https://doi.org/10.1038/s41588-018-0313-7, published online 14 January 2019.

In the version of Fig. 4b initially published, there was a calculation error in the estimates of shared environmental variance (c2) for MaTCH functional domains. For all MaTCH functional domains except the ‘all traits’ functional domain, the estimate of c2 was calculated with monozygotic twin correlation (rMZ) and dizygotic twin correlation (rDZ) for each functional domain provided by the MaTCH website (http://match.ctglab.nl/). The c2 value should have been estimated as c2 = 2rDZrMZ but, owing to a coding error, was erroneously estimated as c2 = 2rDZrDZ. The c2 estimate for the ‘all traits’ functional domain was correct in the version of the article initially published, and therefore no conclusions are affected; however, the contribution of c2 among MaTCH functional domains is decreased. The authors thank G. Gibson and M. Nordborg for pointing out the error.

Fig. 4
figure4

Original and corrected.

To correct this error, Fig. 4 has been revised to include corrected c2 estimates in the data in panel b as well as to include the numbers of phenotypes in both the CaTCH and MaTCH functional domains in the y axes of panels a and b. The number of phenotypes for each MaTCH functional domain in Fig. 4 is based on the number of phenotypes for which h2 and c2 were estimated with twin correlation (rMZ and rDZ) taken from the MaTCH website. The total numbers of phenotypes within each MaTCH functional domain where h2/c2 were estimated with either twin correlation or variance component models (ACE) and can be found in Supplementary Table 1. The legend of Fig. 4 has been revised to include descriptions of the red and blue values and a description of the numbers of phenotypes in the y axes in panels a and b. In the Results section, the description of Fig. 4b reading “For c2, the 95% CI from CaTCH estimates overlapped with the 95% CI from the MaTCH estimates for only the infection domain (Fig. 4b)” has been changed to “For c2, the 95% CI from CaTCH estimates overlapped with the 95% CI from the MaTCH estimates for 11 out of 21 functional domains, namely cardiovascular, dermatological, endocrine, gastrointestinal, hematological, immunological, infection, metabolic, psychiatric, reproduction, and skeletal functional domains (Fig. 4b).”

In the version of the article initially published, the erroneous term ‘depravity index’, appearing throughout the main text, Fig. 1, Supplementary Fig. 10 and the Supplementary Note, should have read ‘deprivation index’.

The errors have been corrected in the HTML and PDF versions of the article.

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Correspondence to Peter M. Visscher or Chirag J. Patel.

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Lakhani, C.M., Tierney, B.T., Manrai, A.K. et al. Author Correction: Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes. Nat Genet 51, 764–765 (2019). https://doi.org/10.1038/s41588-019-0377-z

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