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Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Nature Genetics volume 51, pages 414–430 (2019)Cite this article

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An Author Correction to this article was published on 15 August 2019

This article has been updated

Abstract

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer’s or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal dominant Alzheimer’s disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 × 10−7), indicating that additional rare variants remain to be identified. We also identify important genetic correlations between LOAD and traits such as family history of dementia and education.

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Fig. 1: Manhattan plot of meta-analysis of Stage 1, 2, and 3 results for genome-wide association with Alzheimer’s disease.
Fig. 2: Top prioritized genes of 400 genes located in genome-wide-significant loci.

Data availability

Genome-wide summary statistics for the Stage 1 discovery have been deposited in The National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS)—a NIA/NIH-sanctioned qualified-access data repository, under accession NG00075. Stage 1 data (individual level) for the GERAD cohort can be accessed by applying directly to Cardiff University. Stage 1 ADGC data are deposited in NIAGADS. Stage 1 CHARGE data are accessible by applying to dbGaP for all US cohorts and to Erasmus University for Rotterdam data. AGES primary data are not available owing to Icelandic laws. Stage 2 and Stage 3 primary data are available upon request.

Change history

  • 15 August 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Acknowledgements

We thank all the participants of this study for their contributions. Additional acknowledgements and detailed acknowledgments of funding sources for the study are provided in the Supplementary Note.

Author information

Author notes

  1. These authors contributed equally: Brian W. Kunkle, Benjamin Grenier-Boley, Jean Charles-Lambert, Margaret A. Pericak-Vance.

  2. These authors jointly supervised this work: Agustin Ruiz, Cornelia M. van Duijn, Peter A. Holmans, Sudha Seshadri, Julie Williams, Phillippe Amouyel, Gerard D. Schellenberg, Jean-Charles Lambert, Margaret A. Pericak-Vance.

  3. A list of members and affiliations appears in the Supplementary Note.

Authors and Affiliations

  1. John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA

    Brian W. Kunkle, Eden R. Martin, Kara L. Hamilton-Nelson, Gary W. Beecham, Patrice Whitehead, John R. Gilbert, William R. Perry, Michael L. Cuccaro, Jeffery M. Vance, Susan Slifer & Margaret A. Pericak-Vance

  2. Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France

    Benjamin Grenier-Boley, Vincent Damotte, Céline Bellenguez, Vincent Chouraki, Nathalie Fievet, Phillippe Amouyel & Jean-Charles Lambert

  3. Institut Pasteur de Lille, Lille, France

    Benjamin Grenier-Boley, Vincent Damotte, Céline Bellenguez, Vincent Chouraki, Nathalie Fievet, Phillippe Amouyel & Jean-Charles Lambert

  4. Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France

    Benjamin Grenier-Boley, Vincent Damotte, Céline Bellenguez, Vincent Chouraki, Nathalie Fievet, Phillippe Amouyel & Jean-Charles Lambert

  5. Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK

    Rebecca Sims, Maria Vronskaya, Aura Frizatti, Nandini Badarinarayan, Rachel Raybould, Taniesha Morgan, Nicola Denning, Thomas D. Cushion, Paul Hollingworth, Rachel Marshall, Alun Meggy, Georgina E. Menzies, Ganna Leonenko, Detelina Grozeva, Michael C. O’Donovan, Lesley Jones, Michael J. Owen, Valentina Escott-Price, Peter A. Holmans & Julie Williams

  6. UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK

    Rebecca Sims, Rachel Raybould, Nicola Denning, Thomas D. Cushion, Georgina E. Menzies, Lesley Jones, Valentina Escott-Price & Julie Williams

  7. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA

    Joshua C. Bis, Jennifer A. Brody & Bruce M. Psaty

  8. Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    Adam C. Naj

  9. Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France

    Anne Boland, Robert Olaso, Jean-Guillaume Garnier, Marie-Laure Moutet, Delphine Bacq, Fabienne Garzia, Bertrand Fin, Stéphane Meslage & Jean-Francois Deleuze

  10. Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

    Sven J. van der Lee, Shahzad Ahmad, Hieab H. Adams, Dina Voijnovic, Hata Karamujić-Čomić, Gennady Roshchupkin, Fernando Rivadeneira, A. G. Andre Uitterlinden, Najaf Amin, M. Arfan Ikram & Cornelia M. van Duijn

  11. Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    Alexandre Amlie-Wolf, Amanda B. Kuzma, Otto Valladares, Liming Qu, Yi Zhao, John Malamon, Beth A. Dombroski, Laura B. Cantwell, Mitchell Tang, Li-San Wang & Gerard D. Schellenberg

  12. Framingham Heart Study, Framingham, MA, USA

    Vincent Chouraki, L. Adrienne Cupples, Jayanadra J. Himali, Alexa S. Beiser & Sudha Seshadri

  13. Department of Neurology, Boston University School of Medicine, Boston, MA, USA

    Vincent Chouraki, Jayanadra J. Himali, Alexa S. Beiser, Neil W. Kowall, Ann C. McKee, Robert A. Stern, Lindsay A. Farrer, Anita L. DeStefano & Sudha Seshadri

  14. Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium

    Kristel Sleegers & Christine Van Broeckhoven

  15. Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium

    Kristel Sleegers & Christine Van Broeckhoven

  16. Icelandic Heart Association, Kopavogur, Iceland

    Johanna Jakobsdottir, Gudny Eiriksdottir, Thor Aspelund & Vilmundur Gudnason

  17. Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain

    Sonia Moreno-Grau, Merce Boada, Seung-Hoan Choi, Adelina Orellana, Isabel Hernández, Lluís Tarraga, Itziar de Rojas & Agustin Ruiz

  18. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain

    Sonia Moreno-Grau, Merce Boada, Isabel Hernández, Lluís Tarraga, Itziar de Rojas, Maria J. Bullido, Alberto Lleo, Jordi Clarimon & Agustin Ruiz

  19. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA

    Yuning Chen, Chloe Sarnowski, L. Adrienne Cupples, Jayanadra J. Himali, Shuo Li, Qiong Yang, Alexa S. Beiser, Kathryn L. Lunetta, Lindsay A. Farrer & Anita L. DeStefano

  20. Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

    Mikko Hiltunen, Seppo Helisalmi, Anne Maria Koivisto & Hilkka Soininen

  21. Department of Neurology, Kuopio University Hospital, Kuopio, Finland

    Mikko Hiltunen, Seppo Helisalmi, Anne Maria Koivisto & Hilkka Soininen

  22. Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA

    Badri N. Vardarajan, Sandra Barral, Lawrence S. Honig, Christiane Reitz, Jennifer Williamson & Richard Mayeux

  23. Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA

    Badri N. Vardarajan, Sandra Barral, Christiane Reitz & Richard Mayeux

  24. Department of Neurology, Columbia University, New York, NY, USA

    Badri N. Vardarajan, Sandra Barral & Richard Mayeux

  25. UMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France

    Jacques Epelbaum

  26. Institute of Human Genetics, University of Bonn, Bonn, Germany

    Per Hoffmann & Markus M. Nöthen

  27. Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany

    Per Hoffmann & Markus M. Nöthen

  28. Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland

    Per Hoffmann

  29. School of Biotechnology, Dublin City University, Dublin, Ireland

    Denise Harold

  30. Department of Family Medicine, University of Washington, Seattle, WA, USA

    Annette L. Fitzpatrick

  31. Department of Epidemiology, University of Washington, Seattle, WA, USA

    Annette L. Fitzpatrick, Walter A. Kukull, W. T. Longstreth Jr & Bruce M. Psaty

  32. Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK

    Amy Gerrish, Nick C. Fox, Jonathan M. Schott, Jason D. Warren & Martin Rossor

  33. Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA

    Albert V. Smith

  34. Faculty of Medicine, University of Iceland, Reykjavik, Iceland

    Albert V. Smith & Vilmundur Gudnason

  35. Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA

    Xueqiu Jian & Myriam Fornage

  36. Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy

    Maria Del Zompo & Alessio Squassina

  37. UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK

    Nick C. Fox, Jose Bras & Rita Guerreiro

  38. Neurology Service and CIBERNED, ‘Marqués de Valdecilla’ University Hospital (University of Cantabria and IDIVAL), Santander, Spain

    Ignacio Mateo, Eloy Rodriguez-Rodriguez & Pascual Sanchez-Juan

  39. Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

    Joseph T. Hughes, Yogen Patel, Didier Hannequin, Michelle K. Lupton, Petra Proitsi & John F. Powell

  40. Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain

    Florentino Sanchez-Garcia, Maria Candida Deniz Naranjo, Carmen Munoz-Fernadez & Yolanda A. Benito

  41. Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Makrina Daniilidou, Magda Tsolaki, Despoina Avramidou, Antonia Germanou, Maria Koutroumani & Olymbia Gkatzima

  42. Department of Medicine, University of Washington, Seattle, WA, USA

    Shubhabrata Mukherjee, Wayne C. McCormick, Chang-En Yu & Paul K. Crane

  43. Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France

    David Wallon, Gael Nicolas & Dominique Campion

  44. Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK

    James Uphill, John Collinge, Simon Mead & Natalie S. Ryan

  45. Centre for Public Health, University of Iceland, Reykjavik, Iceland

    Thor Aspelund

  46. Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy

    Daniela Galimberti & Elio Scarpini

  47. University of Milan, Centro Dino Ferrari, Milan, Italy

    Daniela Galimberti & Elio Scarpini

  48. Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria

    Edith Hofer & Reinhold Schmidt

  49. Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria

    Edith Hofer

  50. Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA

    Mariusz Butkiewicz, Will S. Bush, Yuenjoo Song & Jonathan L. Haines

  51. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany

    Johannes Kornhuber

  52. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

    Charles C. White

  53. Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA

    Robert C. Barber & Sid O’Bryant

  54. Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium

    Sebastiaan Engelborghs & Peter P. De Deyn

  55. Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium

    Sebastiaan Engelborghs & Peter P. De Deyn

  56. Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany

    Sabrina Sordon, Manuel Mayhaus, Wei Gu, Matthias Riemenschneider & Thomas Feulner

  57. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Perrie M. Adams

  58. Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium

    Rik Vandenberghe

  59. Department of Neurology, Johns Hopkins University, Baltimore, MD, USA

    Marilyn S. Albert

  60. National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA, USA

    Duane Beekly

  61. Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany

    Annette M. Hartmann & Ina Giegling

  62. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA

    Deborah Blacker

  63. Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA

    Deborah Blacker

  64. Department of Psychiatry, University of Oxford, Oxford, UK

    Simon Lovestone & John Gallacher

  65. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA

    Melissa E. Garcia & Lenore J. Launer

  66. Alzheimer’s Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA

    Rachelle S. Doody

  67. Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK

    Rebecca Sussams & Clive Holmes

  68. Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA

    Honghuang Lin

  69. Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA

    Thomas J. Fairchild

  70. C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA

    Matthew P. Frosch

  71. Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden

    Hakan Thonberg & Caroline Graff

  72. Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden

    Hakan Thonberg & Caroline Graff

  73. German Center for Neurodegenerative Diseases, Bonn, Germany

    Wolfgang Maier & Frank Jessen

  74. Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany

    Wolfgang Maier, Reinhard Heun, Heike Kölsch & Frank Jessen

  75. Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA

    Bernardino Ghetti & Salvatore Spina

  76. Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden

    Vilmantas Giedraitis, Lena Kilander, RoseMarie Brundin, Lars Lannfelt & Martin Ingelsson

  77. Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany

    Amit Kawalia & Alfredo Ramirez

  78. Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Ryan M. Huebinger

  79. Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany

    Susanne Moebus & Karl-Heinz Jöckel

  80. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA

    M. Ilyas Kamboh, James T. Becker & Oscar L. Lopez

  81. Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA

    M. Ilyas Kamboh

  82. Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA

    M. Ilyas Kamboh, Paolo Caffarra & Oscar L. Lopez

  83. Institute of Genetics, Queen’s Medical Centre, University of Nottingham, Nottingham, UK

    James Turton, Jenny Lord, Paolo Caffarra, Kristelle Brown & Christopher Medway

  84. Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA

    Mindy J. Katz & Richard B. Lipton

  85. Section of Neuroscience, DIMEC-University of Parma, Parma, Italy

    Letizia Concari

  86. FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy

    Letizia Concari

  87. Department of Pathology, University of Washington, Seattle, WA, USA

    C. Dirk Keene, Thomas J. Montine & Joshua A. Sonnen

  88. Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland

    Iwona Kloszewska

  89. Mercer’s Institute for Research on Aging, St. James’s Hospital and Trinity College, Dublin, Ireland

    Aoibhinn Lynch, Brian Lawlor & Michael Gill

  90. St. James’s Hospital and Trinity College, Dublin, Ireland

    Aoibhinn Lynch, Brian Lawlor & Michael Gill

  91. Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA

    Eric B. Larson

  92. A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

    Annakaisa Haapasalo

  93. Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA

    Thomas H. Mosley

  94. Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy

    Vincenzo Solfrizzi

  95. Department of Neurology, University of Washington, Seattle, WA, USA

    W. T. Longstreth Jr & Thomas D. Bird

  96. Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy

    Vincenza Frisardi & Francesco Panza

  97. Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain

    Monica Diez-Fairen, Ignacio Alvarez & Pau Pastor

  98. Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain

    Monica Diez-Fairen, Ignacio Alvarez & Pau Pastor

  99. Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands

    Fernando Rivadeneira & A. G. Andre Uitterlinden

  100. Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands

    Fernando Rivadeneira & A. G. Andre Uitterlinden

  101. Department of Neurology, Mayo Clinic, Rochester, MN, USA

    Ronald C. Petersen & Bradley F. Boeve

  102. CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France

    Vincent Deramecourt & Florence Pasquier

  103. Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy

    Francesca Salani, Antonio Ciaramella, Eleonora Sacchinelli & Paola Bossù

  104. School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA

    Eric Boerwinkle

  105. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

    Eric Boerwinkle

  106. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA

    Eric M. Reiman & Matthew J. Huentelman

  107. Arizona Alzheimer’s Consortium, Phoenix, AZ, USA

    Eric M. Reiman

  108. Banner Alzheimer’s Institute, Phoenix, AZ, USA

    Eric M. Reiman

  109. Department of Psychiatry, University of Arizona, Phoenix, AZ, USA

    Eric M. Reiman

  110. Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA

    Jerome I. Rotter

  111. Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Joan S. Reisch

  112. University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France

    Olivier Hanon

  113. Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy

    Chiara Cupidi, Raffaele Giovanni Maletta, Amalia Cecilia Bruni & Maura Gallo

  114. Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA

    Donald R. Royall

  115. University of Bordeaux, Inserm 1219, Bordeaux, France

    Carole Dufouil

  116. Department of Neurology, Bordeaux University Hospital / CHU de Bordeaux, Bordeaux, France

    Carole Dufouil

  117. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Mary Sano & Joseph D. Buxbaum

  118. Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France

    Alexis Brice & Stéphanie Debette

  119. AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France

    Alexis Brice & Stéphanie Debette

  120. Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy

    Roberta Cecchetti, Patrizia Mecocci & Virginia Boccardi

  121. Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK

    Peter St George-Hyslop & David C. Rubinsztein

  122. Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada

    Peter St George-Hyslop & Ekaterina Rogaeva

  123. Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France

    Karen Ritchie & Claudine Berr

  124. Montpellier University, Montpellier, France

    Karen Ritchie & Claudine Berr

  125. Department of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK

    Karen Ritchie

  126. VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA

    Debby W. Tsuang & Thomas D. Bird

  127. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA

    Debby W. Tsuang, Elaine Peskind & Murray Raskind

  128. Institut de la Mémoire et de la Maladie d’Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France

    Bruno Dubois

  129. Institut des Neurosciences Translationnelles de Paris, Institut du Cerveau et de la Moelle Épinière, Paris, France

    Bruno Dubois

  130. Inserm, CNRS, UMR-S975, Institut du Cerveau et de la Moelle Epinière, Paris, France

    Bruno Dubois

  131. Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France

    Bruno Dubois

  132. Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, UK

    David Craig, Bernadette McGuinness, Janet A. Johnston & Peter Passmore

  133. Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA

    Chuang-Kuo Wu

  134. Department of Neurology, University of Michigan, Ann Arbor, MI, USA

    Roger L. Albin & Henry L. Paulson

  135. Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA

    Roger L. Albin

  136. Michigan Alzheimer Disease Center, Ann Arbor, MI, USA

    Roger L. Albin & Henry L. Paulson

  137. Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden

    Laura Fratiglioni & Lina Keller

  138. Indiana Alzheimer’s Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA

    Liana G. Apostolova, Kelley M. Faber, Tatiana M. Foroud & Andrew J. Saykin

  139. Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA

    Liana G. Apostolova & Craig S. Atwood

  140. Department of Neurology, Indiana University, Indianapolis, IN, USA

    Liana G. Apostolova, Craig S. Atwood, Martin R. Farlow & Andrew J. Saykin

  141. Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA

    Liana G. Apostolova & Craig S. Atwood

  142. Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    Steven E. Arnold

  143. Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA

    Sanjay Asthana

  144. Department of Medicine, University of Wisconsin, Madison, WI, USA

    Sanjay Asthana, Chris S. Carlson & Mark A. Sager

  145. Wisconsin Alzheimer’s Disease Research Center, Madison, WI, USA

    Sanjay Asthana & Chris S. Carlson

  146. AXA Research Fund & Sorbonne University Chair, Paris, France

    Harald Hampel

  147. Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France

    Harald Hampel

  148. Brain & Spine Institute, Inserm U 1127, CNRS UMR 7225, Paris, France

    Harald Hampel

  149. Institute of Memory and Alzheimer’s Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France

    Harald Hampel

  150. Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain

    Inés Quintela & Ángel Carracedo

  151. UK Dementia Research Institute, University of Cambridge, Cambridge, UK

    David C. Rubinsztein

  152. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA

    Lisa L. Barnes, Julie A. Schneider, Lei Yu & David Bennett

  153. Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA

    Lisa L. Barnes

  154. Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA

    Lisa L. Barnes, Julie A. Schneider, Lei Yu & David Bennett

  155. Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany

    Lutz Frölich

  156. Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA

    Thomas G. Beach

  157. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA

    James T. Becker & Oscar L. Lopez

  158. Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    James T. Becker

  159. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Eileen H. Bigio

  160. Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Eileen H. Bigio, Marsel Mesulam & Sandra Weintraub

  161. Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

    Michelle K. Lupton

  162. Swedish Medical Center, Seattle, WA, USA

    James D. Bowen & Anna Karydas

  163. Department of Neurology, University of California, San Francisco, San Francisco, CA, USA

    Adam Boxer, Howard J. Rosen & William W. Seeley

  164. Department of Neurology, Duke University, Durham, NC, USA

    James R. Burke & Kathleen A. Welsh-Bohmer

  165. Departments of Biology, Brigham Young University, Provo, UT, USA

    John S. K. Kauwe

  166. University of Kansas Alzheimer’s Disease Center, University of Kansas Medical Center, Kansas City, KS, USA

    Jeffrey M. Burns & Russell H. Swerdlow

  167. Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy

    Michelangelo Mancuso & Ubaldo Bonuccelli

  168. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Joseph D. Buxbaum & Alison M. Goate

  169. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Joseph D. Buxbaum

  170. Department of Pathology and Immunology, Washington University, St. Louis, MO, USA

    Nigel J. Cairns & John C. Morris

  171. Division of Psychiatry, University College London, London, UK

    Andrew McQuillin, Gill Livingston & Nicholas J. Bass

  172. USF Health Byrd Alzheimer’s Institute, University of South Florida, Tampa, FL, USA

    Chuanhai Cao, Andrew N. McDavid, Ashok Raj & Amanda G. Smith

  173. Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Cynthia M. Carlsson

  174. Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK

    John Hardy

  175. Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA

    Regina M. Carney

  176. Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK

    Jose Bras, Rita Guerreiro & Elizabeth Fisher

  177. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA

    Minerva M. Carrasquillo, Mariet Allen, Gina Bisceglio, Li Ma, Neill R. Graff-Radford, Nilifur Ertekin-Taner, Steven G. Younkin & Dennis W. Dickson

  178. Department of Neurology, University of Southern California, Los Angeles, CA, USA

    Helena C. Chui & Lori S. Schneider

  179. Department of Neurology, Catholic University of Rome, Rome, Italy

    Carlo Masullo

  180. Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA

    Elizabeth A. Crocco & Amanda J. Myers

  181. Department of Neurology, University of California, Davis, Sacramento, CA, USA

    Charles DeCarli & John M. Olichney

  182. Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA

    Malcolm Dick & Wayne W. Poon

  183. Wien Center for Alzheimer’s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA

    Ranjan Duara

  184. Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA

    Denis A. Evans

  185. Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

    Angela Hodges

  186. Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany

    Martin Scherer, Hendrik van den Bussche & Joseph F. Quinn

  187. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA

    Kenneth B. Fallon & Joseph F. Quinn

  188. Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA

    David W. Fardo

  189. Department of Psychiatry, New York University, New York, NY, USA

    Steven Ferris & Barry Reisberg

  190. Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

    Markus Leber, Frank Jessen & Alfredo Ramirez

  191. Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany

    Isabella Heuser & Oliver Peters

  192. Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA

    Douglas R. Galasko & Eliezer Masliah

  193. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA

    Marla Gearing

  194. Emory Alzheimer’s Disease Center, Emory University, Atlanta, GA, USA

    Marla Gearing

  195. Department of Psychiatry, University of Freiburg, Freiburg, Germany

    Michael Hüll

  196. Neurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA

    Daniel H. Geschwind

  197. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

    John Morris, Kevin Mayo & Carlos Cruchaga

  198. Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA

    John Morris & Carlos Cruchaga

  199. Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Robert C. Green

  200. Department of Neurology, Washington University, St. Louis, MO, USA

    Kevin Mayo & John C. Morris

  201. Department of Genetics, Washington University, St. Louis, MO, USA

    Kevin Mayo

  202. Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA

    John H. Growdon, Bradley T. Hyman & Rudolph E. Tanzi

  203. Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA

    Ronald L. Hamilton

  204. Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA

    Lindy E. Harrell, Daniel C. Marson & Erik D. Roberson

  205. Cologne Center for Genomics, University of Cologne, Cologne, Germany

    Dmitriy Drichel

  206. Department of Pathology, Duke University, Durham, NC, USA

    Christine M. Hulette

  207. Department of Genome Sciences, University of Washington, Seattle, WA, USA

    Gail P. Jarvik

  208. Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA

    Gail P. Jarvik

  209. Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA

    Erin Abner

  210. Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain

    Lee-Way Jin & Luis M. Real

  211. Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA

    Gyungah R. Jun, Clinton T. Baldwin & Lindsay A. Farrer

  212. Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland

    Giancarlo Russo

  213. Department of Neurology, Oregon Health &Science University, Portland, OR, USA

    Jeffrey A. Kaye

  214. Department of Neurology, Portland Veterans Affairs Medical Center, Portland, OR, USA

    Jeffrey A. Kaye

  215. Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA

    Ronald Kim

  216. Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA

    Neil W. Kowall & Ann C. McKee

  217. Inserm U558, University of Toulouse, Toulouse, France

    Bruno Vellas

  218. Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA

    Joel H. Kramer

  219. Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK

    Emma Vardy

  220. Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA

    Frank M. LaFerla

  221. Department of Neurology, Emory University, Atlanta, GA, USA

    James J. Lah, Allan I. Levey & Thomas S. Wingo

  222. Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany

    Martin Dichgans

  223. German Center for Neurodegenerative Diseases, Munich, Germany

    Martin Dichgans

  224. Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA

    James B. Leverenz

  225. Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

    David Mann, Stuart Pickering-Brown & Nigel M. Hooper

  226. Department of Pathology, University of Michigan, Ann Arbor, MI, USA

    Andrew P. Lieberman

  227. Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany

    Norman Klopp

  228. Helmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany

    H-Erich Wichmann

  229. Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany

    H-Erich Wichmann

  230. Joint Biobank Munich and KORA Biobank, Baltimore, MD, USA

    H-Erich Wichmann

  231. Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA

    Constantine G. Lyketsos

  232. Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK

    Kevin Morgan

  233. Department of Medicine-Pulmonary, New York University, New York, NY, USA

    Frank Martiniuk

  234. Department of Neurology, University of Miami, Miami, FL, USA

    Deborah C. Mash

  235. Department of Pathology, University of California, San Diego, La Jolla, CA, USA

    Eliezer Masliah

  236. Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy

    Antonio Daniele

  237. School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA

    Susan M. McCurry

  238. Institute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK

    Anthony Bayer

  239. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Marsel Mesulam

  240. Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK

    Carol Brayne

  241. Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA

    Bruce L. Miller

  242. Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany

    Steffi Riedel-Heller

  243. Department of Pathology, University of Southern California, Los Angeles, CA, USA

    Carol A. Miller

  244. Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA

    Joshua W. Miller

  245. Institute of Psychiatry, Psychology and Neuroscienceó, King’s College London, London, UK

    Ammar Al-Chalabi & Christopher E. Shaw

  246. UK Dementia Research Institute, King’s College London, London, UK

    Christopher E. Shaw

  247. Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany

    Jens Wiltfang

  248. German Center for Neurodegenerative Diseases, Goettingen, Germany

    Jens Wiltfang

  249. IBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal

    Jens Wiltfang

  250. Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain

    Victoria Alvarez & Eliecer Coto

  251. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

    Joseph E. Parisi

  252. Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA

    Andrew B. Singleton

  253. Department of Neurology, University of California, Irvine, Irvine, CA, USA

    David H. Cribbs & Aimee Pierce

  254. Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy

    Benedetta Nacmias & Sandro Sorbi

  255. Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy

    Benedetta Nacmias

  256. Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA

    Huntington Potter

  257. IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy

    Sandro Sorbi

  258. Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy

    Gianfranco Spalletta, Carlo Caltagirone & Maria Donata Orfei

  259. Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA

    Gianfranco Spalletta

  260. Alzheimer’s Disease Center, New York University, New York, NY, USA

    Barry Reisberg

  261. Oxford Healthy Aging Project, Clinical Trial Service Unit, University of Oxford, Oxford, UK

    Robert Clarke

  262. Department of Epidemiology, Columbia University, New York, NY, USA

    Christiane Reitz

  263. Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK

    A David Smith, Donald Warden & Gordon Wilcock

  264. Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, Los Angeles, CA, USA

    John M. Ringman

  265. Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Roger N. Rosenberg

  266. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK

    Yoav Ben-Shlomo

  267. Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA

    Julie A. Schneider

  268. Department of Psychiatry, University of Southern California, Los Angeles, CA, USA

    Lori S. Schneider

  269. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    John Q. Trojanowski & Vivianna M. Van Deerlin

  270. Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Juan C. Troncoso

  271. Sanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, KY, USA

    Linda J. Van Eldik

  272. Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA

    Harry V. Vinters

  273. Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA

    Harry V. Vinters

  274. Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Pathology, Columbia University, New York, NY, USA

    Jean Paul Vonsattel

  275. Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Sandra Weintraub

  276. Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA

    Kathleen A. Welsh-Bohmer

  277. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Kirk C. Wilhelmsen

  278. Department of Human Genetics, Emory University, Atlanta, GA, USA

    Thomas S. Wingo

  279. Department of Pathology, Oregon Health & Science University, Portland, OR, USA

    Randall L. Woltjer

  280. National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA

    Clinton B. Wright

  281. Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria

    Yasaman Saba & Helena Schmidt

  282. Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

    Alberto Pilotto

  283. Department Geriatric Care, Orthogeriatrics and Rehabilitation, Galliera Hospital, Genova, Italy

    Alberto Pilotto

  284. IdiPAZ, Instituto de Investigación Sanitaria la Paz, Madrid, Spain

    Maria J. Bullido

  285. Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain

    Maria J. Bullido

  286. German Center for Neurodegenerative Diseases, Berlin, Germany

    Oliver Peters

  287. Instituto di Ricovero e Cura a Carattere Scientifico, Associazione Oasi Maria Santissima Srl, Troina, Italy

    Paola Bosco

  288. Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA

    Phil L. De Jager

  289. Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain

    Alberto Lleo & Jordi Clarimon

  290. Somerset Partnership NHS Trust, Somerset, UK

    Nick Warner

  291. The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK

    Panagiotis Deloukas & Rhian Gwilliam

  292. Ronald M. Loeb Center for Alzheimer’s Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Alison M. Goate

  293. University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK

    Patrick G. Kehoe & Seth Love

  294. Department of Neurology, Mayo Clinic, Jacksonville, FL, USA

    Nilifur Ertekin-Taner & Steven G. Younkin

  295. Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France

    Jean-Francois Dartigues

  296. Utah State University, Logan, UT, USA

    Chris Corcoran, JoAnn Tschanz & Ron Munger

  297. Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

    M. Arfan Ikram

  298. Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands

    M. Arfan Ikram

  299. Department of Research Rouvray Psychiatric Hospital, Sotteville-lès-Rouen, France

    Dominique Campion

  300. Department of Neurology, Medical University Graz, Graz, Austria

    Helena Schmidt

  301. Center for Applied Genomics, Children’s Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Hakon Hakonarson

  302. Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Hakon Hakonarson

  303. Department of Ophthalmology, Boston University School of Medicine, Boston University, Boston, MA, USA

    Lindsay A. Farrer

  304. Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA

    Lindsay A. Farrer

  305. Department of Health Services, University of Washington, Seattle, WA, USA

    Bruce M. Psaty

  306. Kaiser Permanente, Washington Health Research Institute, Seattle, WA, USA

    Bruce M. Psaty

  307. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, San Antonio, TX, USA

    Sudha Seshadri

  308. Centre Hospitalier Universitaire de Lille, Lille, France

    Phillippe Amouyel

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  1. Brian W. Kunkle
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