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Doubts about TMEM230 as a gene for parkinsonism

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Fig. 1: Chromosome 20pter-p12 genotyping and mutation analyses.

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Data and DNA samples illustrated in Fig. 1 are available on request, or directly from Ali Rajput (Royal Hospital, University of Saskatchewan). Informed consent was obtained from all subjects, and genetic analyses were performed with ethical approval from the University of British Columbia (H14-00659 DMCBH-Clinicogenetic analyses for Brain Disorders).


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The author thanks I. Guella. J. Follett and A. Milnerwood at the Centre for Applied Neurogenetics for thoughtful discussion, and A. Book, S. Bortnick and D. Evans for technical support. For clinical samples and associated data, the author is indebted to the research participants and their neurologists Alex Rajput and Ali Rajput (Royal Hospital, University of Saskatchewan, Saskatoon, Canada); R.-M. Wu (Taiwan National University Hospital, Taiwan); and S. Appel-Cresswell, M. McKeown and A. J. Stoessl (Pacific Parkinson’s Research Centre, University of British Columbia, Vancouver, Canada).

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Correspondence to Matt J. Farrer.

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The author declares no competing interests.

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Editorial note: the journal apologizes to the authors for the unusual delay in the peer review and publication of this exchange of Correspondence and Reply.

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Farrer, M.J. Doubts about TMEM230 as a gene for parkinsonism. Nat Genet 51, 367–368 (2019).

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