Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Reply to ‘Selective effects of heterozygous protein-truncating variants’

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Data availability

The data supporting the findings of this study will be made available, and can be requested from the authors prior to their publication.

References

  1. Charlesworth, B. & Hill, W. G. Nat. Genet. https://doi.org/10.1038/s41588-018-0291-9 (2018).

  2. Cassa, C. A. et al. Nat. Genet. 49, 806–810 (2017).

    Article  CAS  Google Scholar 

  3. Weghorn, D. et al. Preprint at https://www.biorxiv.org/content/early/2018/10/03/433961 (2018).

  4. Nei, M. Proc. Natl Acad. Sci. USA 60, 517–524 (1968).

    Article  CAS  Google Scholar 

  5. Keinan, A. & Clark, A. G. Science 336, 740–743 (2012).

    Article  CAS  Google Scholar 

  6. Lek, M. et al. Nature 536, 285–291 (2016).

    Article  CAS  Google Scholar 

  7. Tennessen, J. A. et al. Science 337, 64–69 (2012).

    Article  CAS  Google Scholar 

  8. Harpak, A., Bhaskar, A. & Pritchard, J. K. PLoS Genet. 12, e1006489 (2016).

    Article  Google Scholar 

Download references

Acknowledgements

We would like to thank J. Berg, G. Sella, M. Przeworski and A. Kondrashov for their helpful suggestions and feedback.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to David R. Beier or Shamil R. Sunyaev.

Ethics declarations

Competing interests

The authors declare no competing interests.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cassa, C.A., Weghorn, D., Balick, D.J. et al. Reply to ‘Selective effects of heterozygous protein-truncating variants’. Nat Genet 51, 3–4 (2019). https://doi.org/10.1038/s41588-018-0301-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-018-0301-y

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing