News & Views | Published:

INFLAMMATION

Human disease mutations highlight the inhibitory function of TIM-3

Nature Genetics (2018) | Download Citation

A new study identifies loss-of-function mutations in HAVCR2, which encodes TIM-3, in patients with a rare cutaneous T cell lymphoma associated with aberrant immunological activation. These mutations lead to loss of the TIM-3 immunological checkpoint, thus promoting inflammation and malignancy.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Gayden, T. et al. Nat. Genet. https://doi.org/10.1038/s41588-018-0251-4 (2018).

  2. 2.

    Monney, L. et al. Nature 415, 536–541 (2002).

  3. 3.

    Sabatos, C. A. et al. Nat. Immunol. 4, 1102–1110 (2003).

  4. 4.

    Chiba, S. et al. Nat. Immunol. 13, 832–842 (2012).

  5. 5.

    Fourcade, J. et al. J. Exp. Med. 207, 2175–2186 (2010).

  6. 6.

    Jin, H. T. et al. Proc. Natl. Acad. Sci. USA 107, 14733–14738 (2010).

  7. 7.

    Yan, J. et al. PLoS One 8, e58006 (2013).

  8. 8.

    Sakuishi, K. et al. OncoImmunology 2, e23849 (2013).

  9. 9.

    Dardalhon, V. et al. J. Immunol. 185, 1383–1392 (2010).

  10. 10.

    Avery, L., Filderman, J., Szymczak-Workman, A. L. & Kane, L. P. Proc. Natl. Acad. Sci. USA 115, 2455–2460 (2018).

  11. 11.

    Nakayama, M. et al. Blood 113, 3821–3830 (2009).

  12. 12.

    Huang, Y. H. et al. Nature 536, 359 (2016).

  13. 13.

    Zhu, C. et al. Nat. Immunol. 6, 1245–1252 (2005).

  14. 14.

    Leitner, J. et al. PLoS Pathog. 9, e1003253 (2013).

  15. 15.

    Hughes, R. C. Biochim. Biophys. Acta 1473, 172–185 (1999).

Download references

Author information

Affiliations

  1. Ann Romney Center for Neurologic Diseases and Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    • Karen O. Dixon
    • , Madhumita Das
    •  & Vijay K. Kuchroo

Authors

  1. Search for Karen O. Dixon in:

  2. Search for Madhumita Das in:

  3. Search for Vijay K. Kuchroo in:

Competing interests

V.K.K. has patents dealing with intellectual property that have been licensed to Novartis Pharmaceuticals by the Brigham and Women’s Hospital.

Corresponding author

Correspondence to Vijay K. Kuchroo.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41588-018-0289-3

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing