Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Reply to ‘Neutral tumor evolution?’

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Insights from stochastic simulations of cancer growth.
Fig. 2: Detecting subclonal selection with dN/dS analysis.

References

  1. Tarabichi, M. et al. Nat. Genet. https://doi.org/10.1038/s41588-018-0258-x (2018).

  2. Williams, M. J., Werner, B., Barnes, C. P., Graham, T. A. & Sottoriva, A. Nat. Genet. 48, 238–244 (2016).

    Article  CAS  Google Scholar 

  3. Williams, M. J. et al. Nat. Genet. 50, 895–903 (2018).

    Article  CAS  Google Scholar 

  4. Sun, R. et al. Nat. Genet. 49, 1015–1024 (2017).

    Article  CAS  Google Scholar 

  5. Wu, C.-I., Wang, H.-Y., Ling, S. & Lu, X. Annu. Rev. Genet. 50, 347–369 (2016).

    Article  CAS  Google Scholar 

  6. Durrett, R. Ann. Appl. Probab. 23, 230–250 (2013).

    Article  Google Scholar 

  7. Kessler, D. A. & Levine, H. Proc. Natl. Acad. Sci. USA 110, 11682–11687 (2013).

    Article  CAS  Google Scholar 

  8. Kessler, D. A. & Levine, H. J. Stat. Phys. 158, 783–805 (2015).

    Article  Google Scholar 

  9. Bozic, I., Gerold, J. M. & Nowak, M. A. PLOS Comput. Biol. 12, e1004731 (2016).

    Article  Google Scholar 

  10. Temko, D. et al. J. Pathol. 245, 283–296 (2018).

    Article  CAS  Google Scholar 

  11. Nik-Zainal, S. et al. Cell 149, 994–1007 (2012).

    Article  CAS  Google Scholar 

  12. Martincorena, I. et al. Cell 171, 1–3 (2017).

    Article  Google Scholar 

  13. Martincorena, I. & Campbell, P. J. Science 349, 1483–1489 (2015).

    Article  CAS  Google Scholar 

  14. Wang, K. et al. Nat. Genet. 46, 573–582 (2014).

    Article  CAS  Google Scholar 

  15. Zapata, L. et al. Genome Biol. 19, 67 (2018).

Download references

Acknowledgements

A.S. is supported by the Chris Rokos Fellowship in Evolution and Cancer and by Cancer Research UK (A22909). T.A.G. is supported by Cancer Research UK (A19771). C.P.B. is supported by the Wellcome Trust (097319/Z/11/Z). B.W. is supported by a Geoffrey W. Lewis Post-Doctoral Training fellowship. A.S. and T.A.G. are jointly supported by the Wellcome Trust (202778/B/16/Z and 202778/Z/16/Z, respectively). M.J.W. is supported by a Medical Research Council student scholarship.

Author information

Authors and Affiliations

Authors

Contributions

T.H. performed simulation and bioinformatic analyses. L.Z. performed dN/dS analysis. M.J.W. performed additional simulation analysis. B.W. performed mathematical analysis. G.C. provided expertise on clustering analysis. C.P.B., T.A.G. and A.S. conceived and led the study. All authors addressed the criticism and wrote the response.

Corresponding authors

Correspondence to Trevor A. Graham or Andrea Sottoriva.

Supplementary information

Supplementary Text and Figures

Supplementary Methods and Supplementary Figures 1 and 2

Reporting Summary

Supplementary Table 1

Supplementary Table 1

Supplementary Table 2

Supplementary Table 2

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Heide, T., Zapata, L., Williams, M.J. et al. Reply to ‘Neutral tumor evolution?’. Nat Genet 50, 1633–1637 (2018). https://doi.org/10.1038/s41588-018-0256-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-018-0256-z

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer