Reply to ‘Neutral tumor evolution?’

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Insights from stochastic simulations of cancer growth.
Fig. 2: Detecting subclonal selection with dN/dS analysis.

References

  1. 1.

    Tarabichi, M. et al. Nat. Genet. https://doi.org/10.1038/s41588-018-0258-x (2018).

  2. 2.

    Williams, M. J., Werner, B., Barnes, C. P., Graham, T. A. & Sottoriva, A. Nat. Genet. 48, 238–244 (2016).

  3. 3.

    Williams, M. J. et al. Nat. Genet. 50, 895–903 (2018).

  4. 4.

    Sun, R. et al. Nat. Genet. 49, 1015–1024 (2017).

  5. 5.

    Wu, C.-I., Wang, H.-Y., Ling, S. & Lu, X. Annu. Rev. Genet. 50, 347–369 (2016).

  6. 6.

    Durrett, R. Ann. Appl. Probab. 23, 230–250 (2013).

  7. 7.

    Kessler, D. A. & Levine, H. Proc. Natl. Acad. Sci. USA 110, 11682–11687 (2013).

  8. 8.

    Kessler, D. A. & Levine, H. J. Stat. Phys. 158, 783–805 (2015).

  9. 9.

    Bozic, I., Gerold, J. M. & Nowak, M. A. PLOS Comput. Biol. 12, e1004731 (2016).

  10. 10.

    Temko, D. et al. J. Pathol. 245, 283–296 (2018).

  11. 11.

    Nik-Zainal, S. et al. Cell 149, 994–1007 (2012).

  12. 12.

    Martincorena, I. et al. Cell 171, 1–3 (2017).

  13. 13.

    Martincorena, I. & Campbell, P. J. Science 349, 1483–1489 (2015).

  14. 14.

    Wang, K. et al. Nat. Genet. 46, 573–582 (2014).

  15. 15.

    Zapata, L. et al. Genome Biol. 19, 67 (2018).

Download references

Acknowledgements

A.S. is supported by the Chris Rokos Fellowship in Evolution and Cancer and by Cancer Research UK (A22909). T.A.G. is supported by Cancer Research UK (A19771). C.P.B. is supported by the Wellcome Trust (097319/Z/11/Z). B.W. is supported by a Geoffrey W. Lewis Post-Doctoral Training fellowship. A.S. and T.A.G. are jointly supported by the Wellcome Trust (202778/B/16/Z and 202778/Z/16/Z, respectively). M.J.W. is supported by a Medical Research Council student scholarship.

Author information

Affiliations

Authors

Contributions

T.H. performed simulation and bioinformatic analyses. L.Z. performed dN/dS analysis. M.J.W. performed additional simulation analysis. B.W. performed mathematical analysis. G.C. provided expertise on clustering analysis. C.P.B., T.A.G. and A.S. conceived and led the study. All authors addressed the criticism and wrote the response.

Corresponding authors

Correspondence to Trevor A. Graham or Andrea Sottoriva.

Supplementary information

Supplementary Text and Figures

Supplementary Methods and Supplementary Figures 1 and 2

Reporting Summary

Supplementary Table 1

Supplementary Table 1

Supplementary Table 2

Supplementary Table 2

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Heide, T., Zapata, L., Williams, M.J. et al. Reply to ‘Neutral tumor evolution?’. Nat Genet 50, 1633–1637 (2018). https://doi.org/10.1038/s41588-018-0256-z

Download citation

Further reading