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Reply to ‘Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution’

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Fig. 1: Sensitivity of the 1/f test to subclone cancer cell fraction.

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Acknowledgements

A.S. is supported by the Chris Rokos Fellowship in Evolution and Cancer and by Cancer Research UK (A22909). T.A.G. is supported by Cancer Research UK (A19771). C.P.B. is supported by the Wellcome Trust (097319/Z/11/Z). B.W. is supported by the Geoffrey W. Lewis Post-Doctoral Training fellowship. A.S. and T.A.G. are jointly supported by the Wellcome Trust (202778/B/16/Z and 202778/Z/16/Z, respectively). This work was also supported by Wellcome Trust funding to the Centre for Evolution and Cancer (105104/Z/14/Z).

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B.W. performed mathematical analysis. M.J.W. performed simulation analysis. All authors participated in the discussion, conceived and designed the response, and wrote the manuscript.

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Correspondence to Andrea Sottoriva.

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Werner, B., Williams, M.J., Barnes, C.P. et al. Reply to ‘Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution’. Nat Genet 50, 1624–1626 (2018). https://doi.org/10.1038/s41588-018-0235-4

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