Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Fitting neutral-evolution model to genomic data for tumors with different clonality.

Data availability

Methods and supporting data are available in Supplementary Methods.

References

  1. Williams, M. J., Werner, B., Barnes, C. P., Graham, T. A. & Sottoriva, A. Nat. Genet. 48, 238–244 (2016).

    Article  CAS  Google Scholar 

  2. Sims, D., Sudbery, I., Ilott, N. E., Heger, A. & Ponting, C. P. Nat. Rev. Genet. 15, 121–132 (2014).

    Article  CAS  Google Scholar 

  3. Weinstein, J. N. et al. Nat. Genet. 45, 1113–1120 (2013).

    Article  Google Scholar 

  4. Bansal, V. Bioinformatics 26, i318–i324 (2010).

    Article  CAS  Google Scholar 

  5. Andor, N. et al. Nat. Med. 22, 105–113 (2016).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

S.D. acknowledges support from NIH grant P30CA072720.

Author information

Authors and Affiliations

Authors

Contributions

A.B. contributed to data analysis. S.D. conceived the project, contributed to data analysis, interpreted the results, and wrote the manuscript.

Corresponding author

Correspondence to Subhajyoti De.

Ethics declarations

Competing interests

The authors declare no competing interests.

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Balaparya, A., De, S. Revisiting signatures of neutral tumor evolution in the light of complexity of cancer genomic data. Nat Genet 50, 1626–1628 (2018). https://doi.org/10.1038/s41588-018-0219-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-018-0219-4

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer