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Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution

Nature Genetics (2018) | Download Citation

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Acknowledgements

The authors would like to acknowledge discussions with members of the Michor laboratory and with N. Navin, D. Pellman and K. Polyak. This work was supported by the Dana-Farber Cancer Institute Physical Sciences Oncology Center (NCI U54CA193461).

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Author notes

  1. These authors contributed equally: Thomas O. McDonald, Shaon Chakrabarti.

Affiliations

  1. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA

    • Thomas O. McDonald
    • , Shaon Chakrabarti
    •  & Franziska Michor
  2. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA

    • Thomas O. McDonald
    • , Shaon Chakrabarti
    •  & Franziska Michor
  3. Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA, USA

    • Thomas O. McDonald
    •  & Franziska Michor
  4. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA

    • Thomas O. McDonald
    • , Shaon Chakrabarti
    •  & Franziska Michor

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Contributions

T.O.M. and S.C. developed the models, performed simulations and analyzed results. F.M. conceived the idea. All authors wrote the manuscript.

Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Franziska Michor.

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DOI

https://doi.org/10.1038/s41588-018-0217-6

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