Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution

Article metrics

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: A simple branching-process model of tumor evolution.
Fig. 2: An infinite-allele branching-process model of tumor evolution, including sampling as in the original study.
Fig. 3: The model from the original study for multiple simulations.


  1. 1.

    Williams, M. J., Werner, B., Barnes, C. P., Graham, T. A. & Sottoriva, A. Nat. Genet. 48, 238–244 (2016).

  2. 2.

    Sottoriva, A. et al. Nat. Genet. 47, 209–216 (2015).

  3. 3.

    Gerlinger, M. et al. N. Engl. J. Med. 366, 883–892 (2012).

  4. 4.

    Ding, L. et al. Nature 481, 506–510 (2012).

  5. 5.

    Welch, J. S. et al. Cell 150, 264–278 (2012).

  6. 6.

    Chakrabarti, S. & Michor, F. Cancer Res. 77, 3908–3921 (2017).

  7. 7.

    McDonald, T. O. & Michor, F. Bioinformatics 33, 2221–2223 (2017).

  8. 8.

    McDonald, T. O. & Kimmel, M. J. Appl. Probab. 52, 864–876 (2015).

  9. 9.

    Jagers, P. & Nerman, O. Adv. Appl. Probab. 16, 221–259 (1984).

Download references


The authors would like to acknowledge discussions with members of the Michor laboratory and with N. Navin, D. Pellman and K. Polyak. This work was supported by the Dana-Farber Cancer Institute Physical Sciences Oncology Center (NCI U54CA193461).

Author information

T.O.M. and S.C. developed the models, performed simulations and analyzed results. F.M. conceived the idea. All authors wrote the manuscript.

Correspondence to Franziska Michor.

Ethics declarations

Competing interests

The authors declare no competing interests.

Supplementary information

Reporting Summary

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Further reading