Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: A simple branching-process model of tumor evolution.
Fig. 2: An infinite-allele branching-process model of tumor evolution, including sampling as in the original study.
Fig. 3: The model from the original study for multiple simulations.

References

  1. Williams, M. J., Werner, B., Barnes, C. P., Graham, T. A. & Sottoriva, A. Nat. Genet. 48, 238–244 (2016).

    Article  CAS  Google Scholar 

  2. Sottoriva, A. et al. Nat. Genet. 47, 209–216 (2015).

    Article  CAS  Google Scholar 

  3. Gerlinger, M. et al. N. Engl. J. Med. 366, 883–892 (2012).

    Article  CAS  Google Scholar 

  4. Ding, L. et al. Nature 481, 506–510 (2012).

    Article  CAS  Google Scholar 

  5. Welch, J. S. et al. Cell 150, 264–278 (2012).

    Article  CAS  Google Scholar 

  6. Chakrabarti, S. & Michor, F. Cancer Res. 77, 3908–3921 (2017).

    Article  CAS  Google Scholar 

  7. McDonald, T. O. & Michor, F. Bioinformatics 33, 2221–2223 (2017).

    Article  CAS  Google Scholar 

  8. McDonald, T. O. & Kimmel, M. J. Appl. Probab. 52, 864–876 (2015).

    Article  Google Scholar 

  9. Jagers, P. & Nerman, O. Adv. Appl. Probab. 16, 221–259 (1984).

    Article  Google Scholar 

Download references

Acknowledgements

The authors would like to acknowledge discussions with members of the Michor laboratory and with N. Navin, D. Pellman and K. Polyak. This work was supported by the Dana-Farber Cancer Institute Physical Sciences Oncology Center (NCI U54CA193461).

Author information

Authors and Affiliations

Authors

Contributions

T.O.M. and S.C. developed the models, performed simulations and analyzed results. F.M. conceived the idea. All authors wrote the manuscript.

Corresponding author

Correspondence to Franziska Michor.

Ethics declarations

Competing interests

The authors declare no competing interests.

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

McDonald, T.O., Chakrabarti, S. & Michor, F. Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution. Nat Genet 50, 1620–1623 (2018). https://doi.org/10.1038/s41588-018-0217-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-018-0217-6

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer