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COSMIC-3D provides structural perspectives on cancer genetics for drug discovery

Nature Genetics volume 50, pages1200–1202(2018)Cite this article

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Fig. 1: Individual views of mutation, mutation frequency and protein sequence in COSMIC-3D.

References

  1. 1.

    Forbes, S. A. et al. Nucleic Acids Res. 45 (D1), D777–D783 (2017).

  2. 2.

    Berman, H. M. et al. Curr. Opin. Struct. Biol. 40, 17–22 (2016).

    CAS  Article  Google Scholar 

  3. 3.

    Velankar, S. et al. Nucleic Acids Res. 41, D483–D489 (2013).

    CAS  Article  Google Scholar 

  4. 4.

    Futreal, P. A. et al. Nat. Rev. Cancer 4, 177–183 (2004).

    CAS  Article  Google Scholar 

  5. 5.

    Rose, A. S. & Hildebrand, P. W. Nucleic Acids Res. 43 (W1), W576–W579 (2015).

  6. 6.

    UniProt Consortium. Nucleic Acids Res. 45, D158–D169 (2017).

    Article  Google Scholar 

  7. 7.

    Le Guilloux, V., Schmidtke, P. & Tuffery, P. BMC Bioinformatics 10, 168 (2009).

    Article  Google Scholar 

  8. 8.

    Gilmer, T. M. et al. Cancer Res. 68, 571–579 (2008).

    CAS  Article  Google Scholar 

  9. 9.

    Gazdar, A. F. Oncogene 28 (Suppl. 1), S24–S31 (2009).

Download references

Acknowledgements

We thank colleagues at the Wellcome Sanger Institute and Astex Pharmaceuticals for helpful comments. This work was funded by a postdoctoral fellowship awarded to H.C.J. under the Sustaining Innovation Postdoctoral Training Program at Astex Pharmaceuticals (H.C.J., H.K.S., M.L.V., S.A.F.). This work was supported by a Wellcome Trust grant (206194) (H.C.J., S.A.F.).

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Affiliations

  1. COSMIC, Wellcome Sanger Institute, Cambridge, UK

    Harry C. Jubb & Simon A. Forbes

  2. Astex Pharmaceuticals, Cambridge, UK

    Harry C. Jubb, Harpreet K. Saini & Marcel L. Verdonk

Authors
  1. Harry C. Jubb
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  2. Harpreet K. Saini
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  3. Marcel L. Verdonk
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  4. Simon A. Forbes
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Contributions

H.C.J. contributed experimental design, performed the experiments, analyzed the data and wrote the manuscript. H.K.S., M.L.V. and S.A.F. contributed joint supervision of research, conception and design of the experiments, and writing of the manuscript.

Corresponding author

Correspondence to Harry C. Jubb.

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Competing interests

COSMIC-3D uses data and systems infrastructure from the COSMIC database group, which is partly funded from Wellcome Trust charitable funds together with sales of licenses to for-profit enterprises. H.K.S. and M.L.V. are employed by Astex Pharmaceuticals.

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Jubb, H.C., Saini, H.K., Verdonk, M.L. et al. COSMIC-3D provides structural perspectives on cancer genetics for drug discovery. Nat Genet 50, 1200–1202 (2018). https://doi.org/10.1038/s41588-018-0214-9

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