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COSMIC-3D provides structural perspectives on cancer genetics for drug discovery

Nature Geneticsvolume 50pages12001202 (2018) | Download Citation

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  1. 1.

    Forbes, S. A. et al. Nucleic Acids Res. 45 (D1), D777–D783 (2017).

  2. 2.

    Berman, H. M. et al. Curr. Opin. Struct. Biol. 40, 17–22 (2016).

  3. 3.

    Velankar, S. et al. Nucleic Acids Res. 41, D483–D489 (2013).

  4. 4.

    Futreal, P. A. et al. Nat. Rev. Cancer 4, 177–183 (2004).

  5. 5.

    Rose, A. S. & Hildebrand, P. W. Nucleic Acids Res. 43 (W1), W576–W579 (2015).

  6. 6.

    UniProt Consortium. Nucleic Acids Res. 45, D158–D169 (2017).

  7. 7.

    Le Guilloux, V., Schmidtke, P. & Tuffery, P. BMC Bioinformatics 10, 168 (2009).

  8. 8.

    Gilmer, T. M. et al. Cancer Res. 68, 571–579 (2008).

  9. 9.

    Gazdar, A. F. Oncogene 28 (Suppl. 1), S24–S31 (2009).

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We thank colleagues at the Wellcome Sanger Institute and Astex Pharmaceuticals for helpful comments. This work was funded by a postdoctoral fellowship awarded to H.C.J. under the Sustaining Innovation Postdoctoral Training Program at Astex Pharmaceuticals (H.C.J., H.K.S., M.L.V., S.A.F.). This work was supported by a Wellcome Trust grant (206194) (H.C.J., S.A.F.).

Author information


  1. COSMIC, Wellcome Sanger Institute, Cambridge, UK

    • Harry C. Jubb
    •  & Simon A. Forbes
  2. Astex Pharmaceuticals, Cambridge, UK

    • Harry C. Jubb
    • , Harpreet K. Saini
    •  & Marcel L. Verdonk


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H.C.J. contributed experimental design, performed the experiments, analyzed the data and wrote the manuscript. H.K.S., M.L.V. and S.A.F. contributed joint supervision of research, conception and design of the experiments, and writing of the manuscript.

Competing interests

COSMIC-3D uses data and systems infrastructure from the COSMIC database group, which is partly funded from Wellcome Trust charitable funds together with sales of licenses to for-profit enterprises. H.K.S. and M.L.V. are employed by Astex Pharmaceuticals.

Corresponding author

Correspondence to Harry C. Jubb.

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