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DISEASE GENETICS

Genetic risks and clinical rewards

Individual genome-wide polygenic risk scores (GPSs) for assessing disease susceptibility have been shown to yield both reliable and clinically meaningful results. However, certain impediments and outdated ways of thinking about health maintenance must be overcome before GPSs are adopted in routine care streams.

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Fig. 1: Example conditional risk probabilites assuming two diseases are of interest.

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Correspondence to Nicholas J. Schork.

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Schork, A.J., Schork, M.A. & Schork, N.J. Genetic risks and clinical rewards. Nat Genet 50, 1210–1211 (2018). https://doi.org/10.1038/s41588-018-0213-x

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