Supplementary Figure 3: Predicted versus observed prevalence of four diseases according to genome-wide polygenic score percentile. | Nature Genetics

Supplementary Figure 3: Predicted versus observed prevalence of four diseases according to genome-wide polygenic score percentile.

From: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Supplementary Figure 3

ad, For each individual within the UK Biobank testing dataset, the predicted probability of disease was calculated using a logistic regression model with only the genome-wide polygenic score (GPS) as a predictor. The predicted prevalence of disease within each percentile bin of the GPS distribution was calculated as the average predicted probability of all individuals within that bin. The shape of the predicted risk gradient was consistent with the empirically observed risk gradient, reflected by black and blue dots, respectively, for each of four diseases: atrial fibrillation (a), type 2 diabetes (b), inflammatory bowel disease (c), and breast cancer (d). Breast cancer analys is was restricted to female participants.

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