a–c, Three polygenic scores for coronary artery disease were calculated within the UK Biobank testing dataset of 288,978 participants: a previously published score comprising 50 variants that had achieved genome-wide levels of statistical significance in previous studies (Eur. Heart J. 37, 561–567, 2016) (a); a previously published score comprising 49,310 variants derived from a Metabochip GWAS (Eur. Heart J. 37, 3267–3278, 2016) (b); and the newly derived genome-wide polygenic score comprising 6,630,150 variants (c). For each score, the population was divided into 100 bins according to percentile of the score and prevalence of coronary artery disease within each bin plotted. The prevalence of coronary artery disease across score percentiles ranged from 1.4% to 5.9% for the 50-variant score, 1.0% to 7.2% for the 49,310-variant score, and 0.8% to 11.1% for the 6,630,150-variant genome-wide polygenic score.