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Reply to: ‘Subfunctionalization versus neofunctionalization after whole-genome duplication’

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Fig. 1: Models for gene evolution after whole-genome duplication.


  1. 1.

    Sandve, S. R., Rohlfs, R. & Hvidsten, T. R. Nat. Genet. (2018).

  2. 2.

    Braasch, I. et al. Nat. Genet. 48, 427–437 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. 3.

    Lien, S. et al. Nature 533, 200–205 (2016).

    Article  PubMed  CAS  Google Scholar 

  4. 4.

    Force, A. et al. Genetics 151, 1531–1545 (1999).

  5. 5.

    Ohno, S. Evolution by Gene Duplication (Springer, Berlin, 1970) .

  6. 6.

    Inoue, J., Sato, Y., Sinclair, R., Tsukamoto, K. & Nishida, M. Proc. Natl. Acad. Sci. USA 112, 14918–14923 (2015).

  7. 7.

    Blanc, G. & Wolfe, K. H. Plant Cell 16, 1679–1691 (2004).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. 8.

    Moore, R. C. & Purugganan, M. D. Curr. Opin. Plant Biol. 8, 122–128 (2005).

    Article  PubMed  CAS  Google Scholar 

  9. 9.

    Brunet, F. G. et al. Mol. Biol. Evol. 23, 1808–1816 (2006).

    Article  PubMed  CAS  Google Scholar 

Download references


This work was supported by US National Institutes of Health grants R01 OD011116 (alias R01 RR020833) and R24 OD01119004 (J.H.P.); a Feodor Lynen Fellowship from the Alexander von Humboldt Foundation and the Volkswagen Foundation Initiative Evolutionary Biology, grant I/84 815 (I.B.); and Agence Nationale de la Recherche (ANR) grant ANR-10-GENM-017 (PhyloFish; J.B. and Y.G.).

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I.B., J.B., Y.G. and J.H.P. designed studies, conducted studies, analyzed data and wrote the letter.

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Correspondence to John H. Postlethwait.

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The authors declare no competing interests.

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Braasch, I., Bobe, J., Guiguen, Y. et al. Reply to: ‘Subfunctionalization versus neofunctionalization after whole-genome duplication’ . Nat Genet 50, 910–911 (2018).

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