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HUMAN GENETICS

Sizing up whole-genome sequencing studies of common diseases

Nature Geneticsvolume 50pages635637 (2018) | Download Citation

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The triplet code underpins analyses of rare and de novo mutations in exome sequencing data, but analysis of the noncoding genome is much more challenging. A new analytical framework for common, complex diseases highlights the need for very large samples to overcome the unavoidable multiple-testing burden and hence provides preemptive warnings against underpowered studies.

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Affiliations

  1. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

    • Naomi R. Wray
    •  & Jacob Gratten
  2. Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia

    • Naomi R. Wray

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Competing interests

The authors declare no competing interests.

Corresponding authors

Correspondence to Naomi R. Wray or Jacob Gratten.

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DOI

https://doi.org/10.1038/s41588-018-0113-0

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