3D GENOMICS

Expanding the toolbox for 3D genomics

The ability to visualize and study the 3D folding of chromosomes in cells has been propelled forward by several major technological advances in the past two decades. Two new studies now further expand the scientific toolbox for studying chromosome conformation by providing novel methodologies for accurate mapping of genome topology and predicting the topological effects of genomic structural variation.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: New methodology for measuring (DLO Hi-C) and modeling (PRISMR) the 3D genome.

References

  1. 1.

    Denker, A. & de Laat, W. Genes Dev. 30, 1357–1382 (2016).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Dekker, J., Rippe, K., Dekker, M. & Kleckner, N. Science 295, 1306–1311 (2002).

    CAS  Article  PubMed  Google Scholar 

  3. 3.

    Bonev, B. & Cavalli, G. Nat. Rev. Genet. 17, 661–678 (2016).

    CAS  Article  PubMed  Google Scholar 

  4. 4.

    Stadhouders, R. et al. Nat. Genet. 50, 238–249 (2018).

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Jhunjhunwala, S., van Zelm, M. C., Peak, M. M. & Murre, C. Cell 138, 435–448 (2009).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Gorkin, D. U., Leung, D. & Ren, B. Cell Stem Cell 14, 762–775 (2014).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. 7.

    Lupiáñez, D. G. et al. Cell 161, 1012–1025 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  8. 8.

    Gröschel, S. et al. Cell 157, 369–381 (2014).

    Article  PubMed  Google Scholar 

  9. 9.

    Lin, D. et al. Nat. Genet. https://doi.org/10.1038/s41588-018-0111-2 (2018).

  10. 10.

    Bianco, S. et al. Nat. Genet. https://doi.org/10.1038/s41588-018-0098-8 (2018).

    PubMed  Google Scholar 

  11. 11.

    Rao, S. S. et al. Cell 159, 1665–1680 (2014).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  12. 12.

    Davies, J. O. et al. Nat. Methods 13, 74–80 (2016).

    CAS  Article  PubMed  Google Scholar 

  13. 13.

    Serra, F. et al. FEBS Lett. 589 (20 Pt. A), 2987–2995 (2015).

    CAS  Article  PubMed  Google Scholar 

  14. 14.

    Zhu, Y. et al. Nat. Commun. 7, 10812 (2016).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  15. 15.

    Sanborn, A. L. et al. Proc. Natl Acad. Sci. USA 112, E6456–E6465 (2015).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Ralph Stadhouders.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Stadhouders, R. Expanding the toolbox for 3D genomics. Nat Genet 50, 634–635 (2018). https://doi.org/10.1038/s41588-018-0112-1

Download citation