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3D GENOMICS

Expanding the toolbox for 3D genomics

Nature Geneticsvolume 50pages634635 (2018) | Download Citation

The ability to visualize and study the 3D folding of chromosomes in cells has been propelled forward by several major technological advances in the past two decades. Two new studies now further expand the scientific toolbox for studying chromosome conformation by providing novel methodologies for accurate mapping of genome topology and predicting the topological effects of genomic structural variation.

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References

  1. 1.

    Denker, A. & de Laat, W. Genes Dev. 30, 1357–1382 (2016).

  2. 2.

    Dekker, J., Rippe, K., Dekker, M. & Kleckner, N. Science 295, 1306–1311 (2002).

  3. 3.

    Bonev, B. & Cavalli, G. Nat. Rev. Genet. 17, 661–678 (2016).

  4. 4.

    Stadhouders, R. et al. Nat. Genet. 50, 238–249 (2018).

  5. 5.

    Jhunjhunwala, S., van Zelm, M. C., Peak, M. M. & Murre, C. Cell 138, 435–448 (2009).

  6. 6.

    Gorkin, D. U., Leung, D. & Ren, B. Cell Stem Cell 14, 762–775 (2014).

  7. 7.

    Lupiáñez, D. G. et al. Cell 161, 1012–1025 (2015).

  8. 8.

    Gröschel, S. et al. Cell 157, 369–381 (2014).

  9. 9.

    Lin, D. et al. Nat. Genet. https://doi.org/10.1038/s41588-018-0111-2 (2018).

  10. 10.

    Bianco, S. et al. Nat. Genet. https://doi.org/10.1038/s41588-018-0098-8 (2018).

  11. 11.

    Rao, S. S. et al. Cell 159, 1665–1680 (2014).

  12. 12.

    Davies, J. O. et al. Nat. Methods 13, 74–80 (2016).

  13. 13.

    Serra, F. et al. FEBS Lett. 589 (20 Pt. A), 2987–2995 (2015).

  14. 14.

    Zhu, Y. et al. Nat. Commun. 7, 10812 (2016).

  15. 15.

    Sanborn, A. L. et al. Proc. Natl Acad. Sci. USA 112, E6456–E6465 (2015).

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Author information

Affiliations

  1. Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands

    • Ralph Stadhouders
  2. Department of Cell Biology, Erasmus MC, Rotterdam, The Netherlands

    • Ralph Stadhouders

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  1. Search for Ralph Stadhouders in:

Competing interests

The author declares no competing interests.

Corresponding author

Correspondence to Ralph Stadhouders.

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DOI

https://doi.org/10.1038/s41588-018-0112-1

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