The ability to visualize and study the 3D folding of chromosomes in cells has been propelled forward by several major technological advances in the past two decades. Two new studies now further expand the scientific toolbox for studying chromosome conformation by providing novel methodologies for accurate mapping of genome topology and predicting the topological effects of genomic structural variation.
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Stadhouders, R. Expanding the toolbox for 3D genomics. Nat Genet 50, 634–635 (2018). https://doi.org/10.1038/s41588-018-0112-1