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CANCER GENETICS

Evaluating tumor-suppressor gene combinations

Nature Geneticsvolume 50pages480482 (2018) | Download Citation

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In vivo verification of tumor suppressors and their interactions with each other has required complex experiments. A report in this issue uses a novel CRISPR–Cas9 technology with barcodes to test, in parallel, the tumorigenic potential of functional loss of multiple tumor-suppressor genes in the context of a genetically engineered mouse model of lung adenocarcinoma with mutant Kras.

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Author information

Affiliations

  1. Department of Internal Medicine, Division of Hematology-Oncology, University of Texas Southwestern, Dallas, TX, USA

    • James Kim
    •  & John D. Minna
  2. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern, Dallas, TX, USA

    • James Kim
    •  & John D. Minna
  3. Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern, Dallas, TX, USA

    • James Kim
    •  & John D. Minna
  4. Department of Pharmacology, University of Texas Southwestern, Dallas, TX, USA

    • John D. Minna

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to James Kim.

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DOI

https://doi.org/10.1038/s41588-018-0095-y

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