Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Genetics of lipid metabolism in prostate cancer

Dysregulated lipid metabolism is a prominent feature of prostate cancers. Two papers in this issue identify novel genomic drivers of lipid metabolism in prostate cancer and provide implications for the subtyping and treatment of the disease.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Schematic diagram showing two genomic drivers of aberrant lipid metabolism contributing to tumor growth and metastasis in prostate cancer (CaP).


  1. Butler, L. M., Centenera, M. M. & Swinnen, J. V. Endocr. Relat. Cancer 23, R219–R227 (2016).

    Article  CAS  Google Scholar 

  2. Schuster, D. M., Nanni, C. & Fanti, S. Semin. Nucl. Med. 46, 507–521 (2016).

    Article  Google Scholar 

  3. Migita, T. et al. J. Natl. Cancer Inst. 101, 519–532 (2009).

    Article  CAS  Google Scholar 

  4. Sadowski, M. C. et al. Oncotarget 5, 9362–9381 (2014).

    Article  Google Scholar 

  5. Kridel, S. J., Axelrod, F., Rozenkrantz, N. & Smith, J. W. Cancer Res. 64, 2070–2075 (2004).

    Article  CAS  Google Scholar 

  6. Allott, E. H., Masko, E. M. & Freedland, S. J. Eur. Urol. 63, 800–809 (2013).

    Article  CAS  Google Scholar 

  7. Chen, J. et al. Nat. Genet. (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Chen, M. et al. Nat. Genet. (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Wellen, K. E. et al. Science 324, 1076–1080 (2009).

    Article  CAS  Google Scholar 

  10. Cucchiara, V. et al. Eur. Urol. (2017).

    Article  PubMed  Google Scholar 

  11. Lamy, P. J. et al. Eur. Urol. Focus. (2017).

    Article  PubMed  Google Scholar 

  12. Priolo, C. et al. Cancer Res. 74, 7198–7204 (2014).

    Article  CAS  Google Scholar 

  13. Baena, E. et al. Genes Dev. 27, 683–698 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ian G. Mills.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Poulose, N., Amoroso, F., Steele, R. et al. Genetics of lipid metabolism in prostate cancer. Nat Genet 50, 169–171 (2018).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer