Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Is H3K4me1 at enhancers correlative or causative?

H3K4me1 is enriched at active and primed enhancers. However, whether H3K4me1 controls or simply correlates with enhancer activity and function has remained unclear. Several recent reports, including two in Nature Genetics, provide major mechanistic and functional insights into the role of H3K4me1 at enhancers.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: H3K4me1 at enhancers: a chicken or the egg problem?


  1. 1.

    ENCODE Project Consortium. Nature 489, 57–74 (2012).

    Google Scholar 

  2. 2.

    Smith, E. & Shilatifard, A. Nat. Struct. Mol. Biol. 21, 210–219 (2014).

    CAS  Article  Google Scholar 

  3. 3.

    Creyghton, M. P. et al. Proc. Natl. Acad. Sci. USA 107, 21931–21936 (2010).

    CAS  Google Scholar 

  4. 4.

    Heintzman, N. D. et al. Nature 459, 108–112 (2009).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Rada-Iglesias, A. et al. Nature 470, 279–283 (2011).

    CAS  Article  Google Scholar 

  6. 6.

    Dorighi, K. M. et al. Mol. Cell 66, 568–576 (2017).

    CAS  Article  Google Scholar 

  7. 7.

    Local, A. et al. Nat. Genet. (2017).

    Article  Google Scholar 

  8. 8.

    Rickels, R. et al. Nat. Genet. 49, 1647–1653 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Wysocka, J. et al. Cell 121, 859–872 (2005).

    CAS  Article  Google Scholar 

  10. 10.

    Alver, B. H. et al. Nat. Commun. 8, 14648 (2017).

    Article  Google Scholar 

  11. 11.

    Herz, H.-M. et al. Genes Dev. 26, 2604–2620 (2012).

    CAS  Article  Google Scholar 

  12. 12.

    Lagha, M., Bothma, J. P. & Levine, M. Trends Genet. 28, 409–416 (2012).

    CAS  Article  Google Scholar 

  13. 13.

    Wang, A. et al. Cell Stem Cell 16, 386–399 (2015).

    CAS  Article  Google Scholar 

  14. 14.

    Stadler, M. B. et al. Nature 480, 490–495 (2011).

    CAS  Article  Google Scholar 

  15. 15.

    Ooi, S. K. T. et al. Nature 448, 714–717 (2007).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Alvaro Rada-Iglesias.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rada-Iglesias, A. Is H3K4me1 at enhancers correlative or causative?. Nat Genet 50, 4–5 (2018).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing