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ENHANCER EPIGENETICS

Is H3K4me1 at enhancers correlative or causative?

H3K4me1 is enriched at active and primed enhancers. However, whether H3K4me1 controls or simply correlates with enhancer activity and function has remained unclear. Several recent reports, including two in Nature Genetics, provide major mechanistic and functional insights into the role of H3K4me1 at enhancers.

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Fig. 1: H3K4me1 at enhancers: a chicken or the egg problem?

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Correspondence to Alvaro Rada-Iglesias.

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Rada-Iglesias, A. Is H3K4me1 at enhancers correlative or causative?. Nat Genet 50, 4–5 (2018). https://doi.org/10.1038/s41588-017-0018-3

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