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Mapping regulatory variants in hiPSC models

Nature Geneticsvolume 50pages12 (2018) | Download Citation

A new study illustrates the power of the human induced pluripotent stem cell (hiPSC) platform by studying hiPSC-derived sensory neurons from 107 individuals. In addition to identifying thousands of quantitative trait loci influencing gene expression, chromatin accessibility and RNA splicing, the work highlights several underappreciated challenges in the hiPSC field.

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Author information

Affiliations

  1. Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    • Gabriel E. Hoffman
    •  & Kristen J. Brennand
  2. Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    • Gabriel E. Hoffman
    •  & Kristen J. Brennand
  3. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    • Kristen J. Brennand
  4. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    • Kristen J. Brennand
  5. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    • Kristen J. Brennand

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Gabriel E. Hoffman or Kristen J. Brennand.

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DOI

https://doi.org/10.1038/s41588-017-0017-4

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