A method using retron recombineering for phage genome modification may facilitate access to therapeutic phages.
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References
Eskenazi, A. et al. Nat. Commun. 13, 302 (2022).
Gencay, Y. E. et al. Nat. Biotechnol. 42, 265–274 (2024).
Dedrick, R. M. et al. Nat. Med. 25, 730–733 (2019).
Fishman, C. B. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02370-5 (2024).
Mahler, M., Costa, A. R., van Beljouw, S. P. B., Fineran, P. C. & Brouns, S. J. J. Trends Biotechnol. 41, 669–685 (2023).
Millman, A. et al. Cell 183, 1551–1561.e12 (2020).
Yee, T., Furuichi, T., Inouye, S. & Inouye, M. Cell 38, 203–209 (1984).
Simon, A. J., Ellington, A. D. & Finkelstein, I. J. Nucleic Acids Res. 47, 11007–11019 (2019).
Doron, S. et al. Science 359, eaar4120 (2018).
Georjon, H. & Bernheim, A. Nat. Rev. Microbiol. 21, 686–700 (2023).
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R.S. is a scientific cofounder and advisor of BiomX and Ecophage. I.O. declares no competing interests.
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Osterman, I., Sorek, R. Phage genome engineering with retrons. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02392-z
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DOI: https://doi.org/10.1038/s41587-024-02392-z