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Next-generation patient models for colorectal cancer research

Lab-grown ‘mini-colons’ enable the simulation of colorectal tumor dynamics and the high-resolution study of interactions with cells from the tumor’s native microenvironment. These next-generation organoids offer a wealth of new experimental opportunities, propelling the frontiers of cancer modeling in multiple directions.

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Fig. 1: High-resolution analysis of tumor dynamics in CRC mini-colons.


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This is a summary of: Lorenzo-Martín, L. F. et al. Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity. Nat. Biotechnol. (2024).

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Next-generation patient models for colorectal cancer research. Nat Biotechnol (2024).

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