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Drug design

Designing drugs with reversible activity

A strategy for creating drugs that can be quickly neutralized is demonstrated for anticoagulants.

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Fig. 1: Schematic representation of DNA and PNA derivatives and their pharmaceutical applications.


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Correspondence to Dario Neri.

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Competing interests

D.N. is co-founder, CEO and shareholder of Philogen, a biotech company that works (among other things) in the field of DNA-encoded chemical libraries.

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Neri, D. Designing drugs with reversible activity. Nat Biotechnol (2024).

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