Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Stem cells

Modeling human trunk development

A model of the embryonic human trunk attains a more mature developmental stage than previous models.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: A stem cell-derived model of human trunk development recapitulates spinal cord differentiation and patterning.


  1. Sanaki-Matsumiya, M. et al. Nat. Commun. 13, 2325 (2022).

  2. Miao, Y. et al. Nature (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Yamanaka, Y. et al. Nature (2022).

    Article  PubMed  Google Scholar 

  4. Anand, G. M. et al. Cell 186, 497–512.e23 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Yaman, Y. I. & Ramanathan, S. Cell 186, 513–527.e19 (2023).

    Article  CAS  PubMed  Google Scholar 

  6. van den Brink, S. C. et al. Nature 582, 405–409, (2020).

    Article  CAS  PubMed  Google Scholar 

  7. Veenvliet, J. V. et al. Science 370, eaba4937 (2020).

  8. Gribaudo, S. et al. Nat. Biotechnol. (2023).

    Article  PubMed  Google Scholar 

  9. Bénazéraf, B. & Pourquié, O. Annu. Rev. Cell Dev. Biol. 29, 1–26 (2013).

    Article  PubMed  Google Scholar 

  10. Binagui-Casas, A., Dias, A., Guillot, C., Metzis, V. & Saunders, D. Curr. Opin. Cell Biol. 73, 133–140 (2021).

    Article  CAS  PubMed  Google Scholar 

  11. Duboule, D. Dev. Biol. 484, 75–87 (2022).

    Article  CAS  PubMed  Google Scholar 

  12. Philippidou, P. & Dasen, J. S. Neuron 80, 12–34 (2013).

    Article  CAS  PubMed  Google Scholar 

  13. Beccari, L. et al. Nature 562, 272–276 (2018).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Olivier Pourquié.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Miao, Y., Pourquié, O. Modeling human trunk development. Nat Biotechnol (2023).

Download citation

  • Published:

  • DOI:


Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research