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Protein engineering

Perfecting antibodies with language models

A general-purpose protein language model rapidly improves antibody properties.

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Fig. 1: Directed evolution with language models.


  1. Hie, B. L. et al. Nat. Biotechnol. (2023).

    Article  PubMed  Google Scholar 

  2. Smith, G. P. Science 228, 1315–1317 (1985).

  3. Arnold, F. Angew. Chem. Int. Edn Engl. 58, 14420–14426 (2019).

  4. Ferruz, N. et al. Nat. Machin. Intell. 4, 521–532 (2022).

  5. Rives, A. et al. Proc. Natl Acad. Sci. USA 118, e2016239118 (2021).

  6. Meier, J. et al. Adv. Neural Inf. Process. Syst. 34, 29287–29303 (2021).

  7. Olsen, T. H. et al. Bioinform. Adv. 2, vbac046 (2022).

  8. Prihoda, D. et al. MAbs 14, 2020203 (2022).

  9. Fowler, D. M. et al. Nat. Methods 11, 801–807 (2014).

  10. Outeiral, C. & Deane, C. M. Preprint at bioRxiv (2022).

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Correspondence to Charlotte M. Deane.

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Outeiral, C., Deane, C.M. Perfecting antibodies with language models. Nat Biotechnol 42, 185–186 (2024).

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