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Xenotransplantation: how close are we?

Nature Biotechnology volume 41, pages 452–460 (2023)Cite this article

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A group of experts reflects on what was learned from the first human transplants of genetically engineered pig organs and what the future of xenotransplantation may hold.

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Fig. 1: Transplantation figures in the United States.
Fig. 2: Longest survival times of pig xenografts in NHPs.

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  • 24 April 2023

    In the version of this article initially published, references to the University of Alabama at Birmingham originally read “University of Alabama”; these have been updated in the HTML and PDF versions of the article.

References

  1. Porrett, P. M. et al. Am. J. Transplant. 22, 1037–1053 (2022).

    Article  PubMed  Google Scholar 

  2. Montgomery, R. A. et al. N. Engl. J. Med. 386, 1889–1898 (2022).

    Article  CAS  PubMed  Google Scholar 

  3. Griffith, B. P. et al. N. Engl. J. Med. 387, 35–44 (2022).

    Article  CAS  PubMed  Google Scholar 

  4. Cunningham, D. A. et al. Trends Cardiovasc. Med. 11, 190–196 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. Scobie, L. et al. J. Immunol. 191, 2907–2915 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Wynyard, S., Nathu, D., Garkavenko, O., Denner, J. & Elliott, R. Xenotransplantation 21, 309–323 (2014).

    Article  PubMed  Google Scholar 

  7. Denner, J. & Tönjes, R. R. Clin. Microbiol. Rev. 25, 318–343 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Niu, D. et al. Science 357, 1303–1307 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Tector, A. J., Mosser, M., Tector, M. & Bach, J.-M. Front. Immunol. 11, 622 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ding, F. et al. Genes Immun. 23, 175–182 (2022).

    Article  CAS  PubMed  Google Scholar 

  11. World Health Organization. First WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, China, 19–21 November 2008 (World Health Organization, 2008).

  12. Kim, S. C. et al. Am. J. Transplant. 19, 2174–2185 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Längin, M. et al. Nature 564, 430–433 (2018).

    Article  PubMed  Google Scholar 

  14. Shah, J. A. et al. Am. J. Transplant. 17, 2178–2185 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Watanabe, H. et al. Xenotransplantation 27, e12552 (2019).

    PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Deputy Editor, Nature Biotechnology https://www.nature.com/nbt

    Kathryn Aschheim

  2. Senior Editor, Nature Biotechnology https://www.nature.com/nbt

    Laura DeFrancesco

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  1. Kathryn Aschheim
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  2. Laura DeFrancesco
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Correspondence to Kathryn Aschheim.

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Aschheim, K., DeFrancesco, L. Xenotransplantation: how close are we?. Nat Biotechnol 41, 452–460 (2023). https://doi.org/10.1038/s41587-023-01730-x

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