The collection of RNAs in a cell reflects its identity and behavior. Although probing these RNAs in the present is commonplace, peering into the past remains challenging. We developed TIGER (transcribed RNAs inferred by genetically encoded records) to record selected RNAs at the single-cell level, enabling us to connect the past with the present.
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References
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This is a summary of: Jiao, C. et al. RNA recording in single bacterial cells using reprogrammed tracrRNAs. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01604-8 (2023).
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Single-cell recording of cellular RNAs in bacteria. Nat Biotechnol 41, 1076–1077 (2023). https://doi.org/10.1038/s41587-022-01625-3
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DOI: https://doi.org/10.1038/s41587-022-01625-3
