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The lysosomal degraders

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Inspired by PROTACs, new degraders are emerging that harness endocytosis and autophagy to send a wide array of targets to the lysosome for destruction.

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Fig. 1: There are multiple pathways to protein degradation.

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  • 24 November 2022

    In the version of this article initially published, the financing listed for PAQ Therapeutics in Table 1, now showing $34 million, appeared initially as $134 million. The table and a summary of spending at the end of the first section have now been updated.

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Garber, K. The lysosomal degraders. Nat Biotechnol 40, 1709–1713 (2022).

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