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Multiplexed mapping of chromatin features at single-cell resolution

Single-cell nanobody-tethered transposition followed by sequencing (scNTT-seq) is a new assay that measures the genome-wide presence of multiple histone modifications and protein–DNA binding sites at single-cell resolution. scNTT-seq generates high-resolution multimodal maps of chromatin states with high accuracy and sensitivity.

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Fig. 1: scNTT-seq provides accurate single-cell multimodal chromatin profiles.


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This is a summary of: Stuart, T. et al. Nanobody-tethered transposition enables multifactorial chromatin profiling at single-cell resolution. Nat. Biotechnol. (2022).

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Multiplexed mapping of chromatin features at single-cell resolution. Nat Biotechnol (2022).

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