We developed a computational method based on Strand-seq that combines nucleosome occupancy and structural variation analysis in single cells to identify the functional effects of somatic structural variants in leukemia. The method revealed the molecular consequences of somatic driver mutations and informed specific therapeutic targeting of a chromothriptic leukemic subclone.
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This is a summary of: Jeong, H. et al. Functional analysis of structural variants in single cells using Strand-seq. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01551-4 (2022).
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Single-cell multi-omics allows functional characterization of structural variants. Nat Biotechnol (2022). https://doi.org/10.1038/s41587-022-01552-3
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DOI: https://doi.org/10.1038/s41587-022-01552-3
