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Plant hormone sensors as scaffolds for biosensor design

Most plant hormone sensors, including the abscisic acid receptor PYR1, function through chemically induced dimerization. Using computationally designed libraries of PYR1, we created high-affinity receptors for 21 structurally diverse ligands, setting the stage for large-scale small-molecule biosensor development

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Fig. 1: PYR1-based biosensors.

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This is a summary of: Beltrán, J. et al. Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01364-5 (2022).

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Plant hormone sensors as scaffolds for biosensor design. Nat Biotechnol (2022). https://doi.org/10.1038/s41587-022-01373-4

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  • DOI: https://doi.org/10.1038/s41587-022-01373-4

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