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First liver transplantation using a graft maintained ex vivo for several days

Our multidisciplinary team used novel perfusion technology to successfully keep an injured liver graft discarded by all other centers alive for several days, allowing proper graft evaluation and repair. The graft was successfully transplanted into a sick patient, who recovered quickly and enjoyed a normal life at one-year follow up.

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Fig. 1: Novel perfusion system to maintain injured donor livers.


  1. Nasralla, D. & Coussious, C. C. A randomized trial of normothermic preservation in liver transplantation. Nature 557, 50–56 (2018). This is the first randomized trial involving normothermic machine perfusion before liver transplantation.

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  2. Eshmuminov, D. & Becker, D. An integrated perfusion machine preserves injured human livers for 1 week. Nat. Biotechnol. 38, 189–198 (2020). This paper reports for the first time preservation of discarded livers for one week.

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  3. Mueller, M. & Hefti, M. L. Long-term normothermic machine preservation of partial livers: first experience with 21 human hemi-livers. Ann. Surg. 274, 836–842 (2021). This paper presents the first experience with partial liver perfusion for one week.

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This is a summary of: Clavien, P.-A. et al. Transplantation of a human liver following 3 days of ex situ normothermic preservation. Nat. Biotechnol. (2022)

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First liver transplantation using a graft maintained ex vivo for several days. Nat Biotechnol 40, 1578–1579 (2022).

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