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Sizing up beta cells made from stem cells

A thorough study of lab-made pancreatic beta cells reveals their differences from primary cells.

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Fig. 1: Physiological characterization of human pluripotent stem cell-derived islets relative to primary islets.


  1. Rezania, A. et al. Nat. Biotechnol. 32, 1121–1133 (2014).

    Article  CAS  Google Scholar 

  2. Pagliuca, F. W. et al. Cell 159, 428–439 (2014).

    Article  CAS  Google Scholar 

  3. Veres, A. et al. Nature 569, 368–373 (2019).

    Article  CAS  Google Scholar 

  4. Augsornworawat, P., Maxwell, K. G., Velazco-Cruz, L. & Millman, J. R. Cell Rep. 32, 108067 (2020).

    Article  CAS  Google Scholar 

  5. Davis, J. C. et al. Cell Rep. 31, 107623 (2020).

    Article  CAS  Google Scholar 

  6. Balboa, D. et al. Nat. Biotechnol. (2021).

  7. Shapiro, A. M. J. et al. N. Engl. J. Med. 343, 230–238 (2000).

    Article  CAS  Google Scholar 

  8. Velazco-Cruz, L. et al. Stem Cell Reports 12, 351–365 (2019).

    Article  CAS  Google Scholar 

  9. Lewandowski, S. L. et al. Cell Metab. 32, 736–750.e735 (2020).

    Article  CAS  Google Scholar 

  10. Campbell, J. E. & Newgard, C. B. Nat. Rev. Mol. Cell Biol. 22, 142–158 (2021).

    Article  CAS  Google Scholar 

  11. Otonkoski, T. et al. Am. J. Hum. Genet. 81, 467–474 (2007).

    Article  CAS  Google Scholar 

  12. Kragl, M. et al. Nat. Commun. 7, 13560 (2016).

    Article  CAS  Google Scholar 

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Correspondence to Maike Sander.

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Nguyen-Ngoc, KV., Wortham, M. & Sander, M. Sizing up beta cells made from stem cells. Nat Biotechnol 40, 1006–1008 (2022).

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