Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

STEM CELLS

Engineered models of the human embryo

Embryo models built from stem cells promise to shed light on human development.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Comparison of early human development in vivo, ex vivo and in blastoid models in vitro.

References

  1. Rossant, J. & Tam, P. P. L. Stem Cell Rep. 16, 1031–1038 (2021).

    Article  Google Scholar 

  2. Warmflash, A. et al. Nat. Methods 11, 847–854 (2014).

    Article  CAS  Google Scholar 

  3. Liu, X. et al. Nature 591, 627–632 (2021).

    Article  CAS  Google Scholar 

  4. Yu, L. et al. Nature 591, 620–626 (2021).

    Article  CAS  Google Scholar 

  5. Sozen, B., Jorgensen, V., Zhu, M., Cui, T. & Zernicka-Goetz, M. Preprint at bioRxiv https://doi.org/10.1101/2021.03.12.435175 (2021).

  6. Fan, Y. et al. Preprint at bioRxiv https://doi.org/10.1101/2021.03.09.434313 (2021).

  7. Yanagida, A. et al. Cell Stem Cell 28, 1016–1022.e4 (2021).

    Article  CAS  Google Scholar 

  8. Zhao, C. et al. Preprint at bioRxiv https://doi.org/10.1101/2021.05.07.442980 (2021).

  9. Shahbazi, M. N. et al. Nat. Cell Biol. 18, 700–708 (2016).

    Article  CAS  Google Scholar 

  10. Deglincerti, A. et al. Nature 533, 251–254 (2016).

    Article  CAS  Google Scholar 

  11. O’Leary, T. et al. Nat. Biotechnol. 30, 278–282 (2012).

    Article  Google Scholar 

  12. Popovic, M. et al. Mol. Hum. Reprod. 25, 519–526 (2019).

    Article  CAS  Google Scholar 

  13. Pereira Daoud, A. M. et al. Hum. Reprod. Update 26, 779–798 (2020).

    Article  Google Scholar 

  14. Rivron, N. C. et al. Nature 557, 106–111 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Mina Popovic or Susana M. Chuva de Sousa Lopes.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Popovic, M., Azpiroz, F. & Chuva de Sousa Lopes, S.M. Engineered models of the human embryo. Nat Biotechnol 39, 918–920 (2021). https://doi.org/10.1038/s41587-021-01004-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41587-021-01004-4

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing