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Artificial intelligence, drug repurposing and peer review

Nature Biotechnology volume 38, pages 1127–1131 (2020)Cite this article

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Can traditional computational analysis and machine learning help compensate for inadequate peer review of drug-repurposing papers in the context of an infodemic?

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Acknowledgements

T.I.O. was supported by the US National Institutes of Health, U24 CA224370. E.B. was supported by Krebsliga Schweiz, BIL KFS 4261-08-2017.

Author information

Author notes

  1. These authors contributed equally: Evelyne Bischof, Alex Zhavoronkov.

Authors and Affiliations

  1. Ovid Therapeutics, Inc, New York, NY, USA

    Jeremy M. Levin

  2. Biotechnology Innovation Organization (BIO), Washington, DC, USA

    Jeremy M. Levin

  3. Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA

    Tudor I. Oprea

  4. Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA

    Tudor I. Oprea

  5. Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

    Tudor I. Oprea

  6. Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Tudor I. Oprea

  7. SparkBeyond, Netanya, Israel

    Sagie Davidovich

  8. Owkin, Paris, France

    Thomas Clozel

  9. Medicines Discovery Catapult, Cheshire, UK

    John P. Overington

  10. Insilico Medicine, Hong Kong Science and Technology Park, Hong Kong, China

    Quentin Vanhaelen, Evelyne Bischof & Alex Zhavoronkov

  11. Retrotope, Inc, Los Altos, CA, USA

    Charles R. Cantor

  12. Shanghai University of Medicine and Health Sciences, College of Clinical Medicine, Shanghai, China

    Evelyne Bischof

  13. Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy

    Evelyne Bischof

Authors
  1. Jeremy M. Levin
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  2. Tudor I. Oprea
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  3. Sagie Davidovich
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  4. Thomas Clozel
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  5. John P. Overington
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  6. Quentin Vanhaelen
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  7. Charles R. Cantor
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  8. Evelyne Bischof
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  9. Alex Zhavoronkov
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Corresponding authors

Correspondence to Evelyne Bischof or Alex Zhavoronkov.

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Competing interests

J.M.L. works for Ovid Therapeutics, a public biotechnology company developing medicines for rare neurological diseases, and is the chairman of the Biotechnology Industry Organization. A.Z. and Q.V. are affiliated with Insilico Medicine, a company developing artificial intelligence solutions for target discovery, small molecule chemistry and prediction of clinical trial outcomes. A.Z. is the CEO of Deep Longevity, an artificial intelligence company. S.D. is CEO of SparkBeyond, an artificial intelligence company. T.C. is CEO of Owkin, an artificial intelligence company specializing in clinical research. T.I.O. has received honoraria from or consulted for Abbott, AstraZeneca, Chiron, Genentech, Infinity Pharmaceuticals, Merz Pharmaceuticals, Merck Darmstadt, Mitsubishi Tanabe, Novartis, Ono Pharmaceuticals, Pfizer, Roche, Sanofi, Wyeth and Insilico Medicine. J.P.O. was previously employed by Pfizer, Inpharmatica, EMBL-EBI and BenevolentAI, and has received honoraria or consulting fees from Insitro, Sanofi and Boehringer Ingelheim. C.R.C. is a founder and a director of Retrotope and an advisor to Insilico Medicine. E.B. is an advisor to Insilico Medicine.

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Editorial note: This article has been peer reviewed.

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Levin, J.M., Oprea, T.I., Davidovich, S. et al. Artificial intelligence, drug repurposing and peer review. Nat Biotechnol 38, 1127–1131 (2020). https://doi.org/10.1038/s41587-020-0686-x

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